Clindamycin

Adults: Clindamycin capsule dosage for adults For serious infections, the adult dose is 150 mg to 300 mg every six hours. For more severe infections, it is 300 mg to 450 mg every six hours. Clindacin capsules should be taken with a full glass of water, which lowers the chance of irritation of the oesophagus. Several studies have found that a Clindamycin 300 mg capsule keeps the plasma concentration above the MIC90 for more than 12 hours. This supports twice-daily dosing of the Clindacin 300 mg capsule, particularly in SSTIs and RTIs. For bone and joint infections and diabetic foot infections, though, the dose of Clindamycin should be one 300 mg capsule 3 to 4 times daily. Clindamycin IV/IM injection for adults For serious infections caused by aerobic gram-positive cocci and the more susceptible anaerobes, the dose is 600 to 1200 mg a day, given in 2 to 4 equal doses. For more severe infections, it is 1200 to 2700 mg a day in 2 to 4 equal doses. In more serious infections these doses may have to be increased. The same applies in life-threatening situations caused by either aerobes or anaerobes. Doses of as much as 4800 mg daily have been given intravenously to adults. A single intramuscular injection of more than 600 mg is not recommended. Treatment can be changed from the injection to Clindamycin hydrochloride capsules when the condition allows, at the doctor's discretion. For (3-hemolytic streptococcal infections, treatment should continue for at least 10 days.