Indications
Choriogonadotropin Alpha alfa injection (Ovidrel alfa injection) is used to bring about the final maturation of follicles and early luteinization in infertile women. These women must have had pituitary desensitization and been properly pretreated with follicle stimulating hormones, as part of an Assisted Reproductive Technology (ART) program such as in vitro fertilization and embryo transfer. The Choriogonadotropin Alpha alfa PreFilled Syringe is also used to induce ovulation (OI) and pregnancy in anovulatory infertile patients whose infertility is functional and not due to primary ovarian failure. Selection of patients Before treatment with gonadotropins starts, a thorough gynecologic and endocrinologic evaluation must be done, including an assessment of pelvic anatomy. Patients with tubal obstruction should receive Choriogonadotropin Alpha Alfa PreFilled Syringe only if they are enrolled in an in vitro fertilization program. Primary ovarian failure should be excluded by measuring gonadotropin levels, and pregnancy should be excluded with an appropriate evaluation. Patients in later reproductive life are more likely to develop endometrial carcinoma, and they also have a higher incidence of anovulatory disorders. So any patient with abnormal uterine bleeding or other signs of endometrial abnormality needs a thorough diagnostic evaluation before FSH and Choriogonadotropin Alpha Alfa PreFilled Syringe therapy begins. The first evaluation should also cover the partner's fertility potential.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Recombinant hCG behaves much like hCG taken from the placenta or from the urine of pregnant women. Its physicochemical, immunological and biological activities are comparable to theirs.
Choriogonadotropin alfa is the active component of Choriogonadotropin Alpha PreFilled Syringe. It is an analogue of Luteinizing Hormone (LH) and binds to the LH/hCG receptor on the granulosa and theca cells of the ovary. Through this action it stimulates late follicular maturation and the resumption of oocyte meiosis, and it starts the rupture of the pre-ovulatory ovarian follicle. All of this happens without an endogenous LH surge.
In pregnancy, hCG is secreted by the placenta. It keeps the corpus luteum viable, so estrogen and progesterone continue to be secreted, and these are needed to support the first trimester of pregnancy.
Choriogonadotropin Alpha PreFilled Syringe is given when monitoring of the patient shows that enough follicular development has occurred in response to FSH treatment for ovulation induction.
Pregnancy & Breastfeeding
Choriogonadotropin Alpha is Pregnancy Category X. In pregnant rats, a dose of urinary-hCG (500 IU), which equals three times the maximum human dose of 10,000 based on body surface area, led to intrauterine death and impaired parturition.
Nursing mothers: nobody knows whether this drug passes into human milk. Many drugs do, so caution should be exercised if hCG is given to a nursing woman.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.