Indications & Uses
Ovidrel is indicated for:
Pharmacology
Recombinant hCG behaves much like hCG taken from the placenta or from the urine of pregnant women. Its physicochemical, immunological and biological activities are comparable to theirs.
Choriogonadotropin alfa is the active component of Choriogonadotropin Alpha PreFilled Syringe. It is an analogue of Luteinizing Hormone (LH) and binds to the LH/hCG receptor on the granulosa and theca cells of the ovary. Through this action it stimulates late follicular maturation and the resumption of oocyte meiosis, and it starts the rupture of the pre-ovulatory ovarian follicle. All of this happens without an endogenous LH surge.
In pregnancy, hCG is secreted by the placenta. It keeps the corpus luteum viable, so estrogen and progesterone continue to be secreted, and these are needed to support the first trimester of pregnancy.
Choriogonadotropin Alpha PreFilled Syringe is given when monitoring of the patient shows that enough follicular development has occurred in response to FSH treatment for ovulation induction.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Infertile women undergoing assisted reproductive technologies (ART)
Give Choriogonadotropin Alfa PreFilled Syringe 250 μg one day after the last dose of the follicle stimulating agent. Don't give it until serum estradiol and vaginal ultrasonography show that the follicles have developed adequately. If the ovaries respond excessively, hold back the injection. Signs of this are clinically significant ovarian enlargement or excessive estradiol production.
Infertile women undergoing ovulation induction (OI)
Choriogonadotropin Alfa PreFilled Syringe should not be given until serum estradiol and vaginal ultrasonography show adequate follicular development. The dose is 250 μg, given one day after the last dose of the follicle stimulating agent. Withhold the injection if the ovarian response is excessive. Here the signs are multiple follicular development, clinically significant ovarian enlargement or excessive estradiol production.
Side Effects
Side effects reported with Choriogonadotropin Alpha include inflammation and other reactions at the injection site, flatulence, diarrhea, hiccup, ectopic pregnancy, breast pain, intermenstrual bleeding, vaginal hemorrhage, cervical lesion, leukorrhea, ovarian hyperstimulation and uterine disorders. Vaginitis and vaginal discomfort can also occur, along with body pain, back pain, fever, dizziness, headache, hot flashes, malaise, paraesthesias, rash, emotional lability and insomnia. Other reported effects are upper respiratory tract infection, cough, dysuria, urinary tract infection, urinary incontinence, albuminuria, cardiac arrhythmia, genital moniliasis, genital herpes, leukocytosis, heart murmur and cervical carcinoma.
Cautions & Contraindications
Warnings & Precautions
Gonadotropins, including Choriogonadotropin Alpha PreFilled Syringe (choriogonadotropin alfa injection), should only be used by physicians who know infertility problems and their management thoroughly. Like other hCG products, Choriogonadotropin Alpha PreFilled Syringe is a potent gonadotropic substance. It can cause Ovarian Hyperstimulation Syndrome (OHSS) in women, with or without pulmonary or vascular complications. The risks of gonadotropin treatment should be considered for women who have risk factors for thromboembolic events, such as a prior medical or family history. Gonadotropin therapy asks for a certain time commitment from physicians and supporting health professionals, and it needs appropriate monitoring facilities to be available. Safe and effective induction of ovulation, and use of Choriogonadotropin Alpha PreFilled Syringe in women, requires regular monitoring of ovarian response with serum estradiol and transvaginal ultrasound.
Contraindications
Choriogonadotropin Alpha PreFilled Syringe should not be given to women who have any of the following: Earlier hypersensitivity to hCG preparations or to any of their excipients. Primary ovarian failure. Thyroid or adrenal dysfunction that is not under control. An organic intracranial lesion that is not under control, such as a pituitary tumor. Abnormal uterine bleeding of undetermined origin. Ovarian cyst or enlargement of undetermined origin. Sex hormone dependent tumors of the reproductive tract and accessory organs. Pregnancy.
Pregnancy & Breastfeeding
Choriogonadotropin Alpha is Pregnancy Category X. In pregnant rats, a dose of urinary-hCG (500 IU), which equals three times the maximum human dose of 10,000 based on body surface area, led to intrauterine death and impaired parturition.
Nursing mothers: nobody knows whether this drug passes into human milk. Many drugs do, so caution should be exercised if hCG is given to a nursing woman.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Children: Choriogonadotropin Alpha has not been shown to be safe or effective in pediatric patients.
Older people: Its safety and effectiveness in geriatric patients have not been established either.
Storage
The Choriogonadotropin Alpha Alfa PreFilled Syringe must be kept in a refrigerator at 2 to 8° C until it is dispensed to the patient. The patient should also keep it refrigerated, so that it can be used up to the expiry date shown on the syringe or carton. If needed, the patient may keep the syringe at room temperature, up to 25° C, for no more than 30 days, and it must be used within those 30 days. Protect it from light and keep it in its original package. Discard any unused material.
Common questions about Ovidrel 250 mcg/0.5 ml
What is Ovidrel 250 mcg/0.5 ml Injection?
Ovidrel 250 mcg/0.5 ml Injection is a medicine that contains Choriogonadotropin Alpha. It is made by Janata Traders. It belongs to the Female Sex hormones group of medicines.
What is Ovidrel used for?
Ovidrel is used for: Cancer.
What are the side effects of Ovidrel?
Side effects reported with Choriogonadotropin Alpha include inflammation and other reactions at the injection site, flatulence, diarrhea, hiccup, ectopic pregnancy, breast pain, intermenstrual bleeding, vaginal hemorrhage, cervical lesion, leukorrhea, ovarian hyperstimulation and uterine disorders. Vaginitis and vaginal discomfort can also occur, along with body pain, back pain, fever, dizziness, headache, hot flashes, malaise, paraesthesias, rash, emotional lability and insomnia.
Can I take Ovidrel during pregnancy or while breastfeeding?
Choriogonadotropin Alpha is Pregnancy Category X. In pregnant rats, a dose of urinary-hCG (500 IU), which equals three times the maximum human dose of 10,000 based on body surface area, led to intrauterine death and impaired parturition. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Ovidrel?
The Choriogonadotropin Alpha Alfa PreFilled Syringe must be kept in a refrigerator at 2 to 8° C until it is dispensed to the patient. The patient should also keep it refrigerated, so that it can be used up to the expiry date shown on the syringe or carton.
Do I need a prescription for Ovidrel?
Ovidrel is a prescription (Rx) medicine. Take it as your doctor advises.