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Cefuroxime Axetil + Clavulanic Acid

Second generation cephalosporins Prescription

Indications

Chronic Obstructive Pulmonary Disease Bronchitis Sinusitis Pharyngitis Tonsillitis Bacterial Infection Respiratory Tract Infection Sepsis Otitis Media

Cefuroxime Axetil + Clavulanic Acid is used to treat infections caused by sensitive bacteria. These are the infections it is indicated for. Pharyngitis and tonsillitis caused by Streptococcus pyogenes. Acute bacterial otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (beta-lactamase producing strains) or Streptococcus pyogenes. Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae (non beta-lactamase producing strains). Lower respiratory tract infections, including pneumonia, caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta lactamase-producing strains), Klebsiella spp., Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains), Streptococcus pyogenes and E. coli. Acute bacterial exacerbation of chronic bronchitis, and secondary bacterial infections of acute bronchitis, caused by Streptococcus pneumoniae, Haemophilus influenzae (beta-lactamase negative strains) or Haemophilus parainfluenzae (beta-lactamase negative strains). Uncomplicated skin and skin-structure infections caused by Staphylococcus aureus (including beta-lactamase producing strains) or Streptococcus pyogenes. Uncomplicated urinary tract infections caused by E. coli or Klebsiella pneumoniae. Bone and joint infections caused by Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains). Uncomplicated gonorrhoea caused by penicillinase-producing and non-penicillinase producing strains of Neisseria gonorrhoeae. Early Lyme disease (erythema migrans) caused by Borrelia burgdorferi. Septicemia caused by Staphylococcus aureus, Streptococcus pneumoniae, E. coli, Haemophilus influenzae (including ampicillin-resistant strains) and Klebsiella spp. Meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae (including ampicillin-resistant strains), Neisseria meningitidis and Staphylococcus aureus (penicillinase and non-penicillinase producing strains). It is also used for switch therapy, that is, changing from an injectable to an oral medicine.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Cefuroxime is a second generation cephalosporin antibiotic that kills bacteria. It works against many Gram-positive and Gram-negative organisms that are susceptible to it, including many strains that produce beta-lactamase. Cefuroxime stops bacteria from building their cell wall, because it interferes with the transpeptidation process.

Clavulanic acid is a beta lactamase inhibitor, taken naturally from Streptomyces clavuligerus. Its structure is similar to that of beta lactam antibiotics, and it binds irreversibly to beta-lactamase enzymes and inactivates them. This way clavulanic acid protects cefuroxime from being broken down by those enzymes. So the combination gives a way to treat bacterial infections caused by beta lactam resistant bacteria.

Pregnancy & Breastfeeding

Doctors try to avoid all antibiotics in the first trimester if they can. Cefuroxime-Clavulanic Acid, though, can be used safely in later pregnancy to treat urinary and other infections. A small amount of Cefuroxime-Clavulanic Acid passes into breast milk, and the possibility of sensitizing the infant should be kept in mind.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Adolescents and adults (13 years and older) For pharyngitis or tonsillitis, Cefuroxime Axetil + Clavulanic Acid is given as 250 mg b.i.d. for 5 to 10 days. Acute bacterial maxillary sinusitis takes 250 mg b.i.d. for 10 days. For an acute bacterial exacerbation of chronic bronchitis, the dose is 250 to 500 mg b.i.d. for 10 days, and for secondary bacterial infections of acute bronchitis it is 250 to 500 mg b.i.d. for 5 to 10 days. Uncomplicated skin and skin structure infections need 250 to 500 mg b.i.d. for 10 days. Uncomplicated urinary tract infections need 250 mg b.i.d. for 7 to 10 days. Uncomplicated gonorrhoea is treated with 1000 mg b.i.d. as a single dose. Community acquired pneumonia takes 250 to 500 mg b.i.d. for 5 to 10 days. MDR typhoid fever takes 500 mg b.i.d. for 10 to 14 days, and early Lyme disease takes 500 mg b.i.d. for 20 days. Paediatric Patients (3 months to 12 years) Pharyngitis or tonsillitis: 20 mg/kg/day b.i.d. for 5 to 10 days. Acute otitis media: 30 mg/kg/day b.i.d. for 10 days. Acute bacterial maxillary sinusitis: 30 mg/kg/day b.i.d. for 10 days. Impetigo: 30 mg/kg/day b.i.d. for 10 days. Food makes no difference, so the Cefuroxime-Clavulanic Acid tablet may be taken with or without it.

Side Effects & Interactions

Side Effects

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