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These brands contain the same active ingredient (Cefuroxime Axetil + Clavulanic Acid). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Clavusef
Other strengths and forms by Opsonin Pharma Limited
Indications & Uses
Pharmacology
Cefuroxime is a second generation cephalosporin antibiotic that kills bacteria. It works against many Gram-positive and Gram-negative organisms that are susceptible to it, including many strains that produce beta-lactamase. Cefuroxime stops bacteria from building their cell wall, because it interferes with the transpeptidation process.
Clavulanic acid is a beta lactamase inhibitor, taken naturally from Streptomyces clavuligerus. Its structure is similar to that of beta lactam antibiotics, and it binds irreversibly to beta-lactamase enzymes and inactivates them. This way clavulanic acid protects cefuroxime from being broken down by those enzymes. So the combination gives a way to treat bacterial infections caused by beta lactam resistant bacteria.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adolescents and adults (13 years and older)
For pharyngitis or tonsillitis, Cefuroxime Axetil + Clavulanic Acid is given as 250 mg b.i.d. for 5 to 10 days. Acute bacterial maxillary sinusitis takes 250 mg b.i.d. for 10 days. For an acute bacterial exacerbation of chronic bronchitis, the dose is 250 to 500 mg b.i.d. for 10 days, and for secondary bacterial infections of acute bronchitis it is 250 to 500 mg b.i.d. for 5 to 10 days.
Uncomplicated skin and skin structure infections need 250 to 500 mg b.i.d. for 10 days. Uncomplicated urinary tract infections need 250 mg b.i.d. for 7 to 10 days. Uncomplicated gonorrhoea is treated with 1000 mg b.i.d. as a single dose. Community acquired pneumonia takes 250 to 500 mg b.i.d. for 5 to 10 days. MDR typhoid fever takes 500 mg b.i.d. for 10 to 14 days, and early Lyme disease takes 500 mg b.i.d. for 20 days.
Paediatric Patients (3 months to 12 years)
Pharyngitis or tonsillitis: 20 mg/kg/day b.i.d. for 5 to 10 days. Acute otitis media: 30 mg/kg/day b.i.d. for 10 days. Acute bacterial maxillary sinusitis: 30 mg/kg/day b.i.d. for 10 days. Impetigo: 30 mg/kg/day b.i.d. for 10 days.
Food makes no difference, so the Cefuroxime-Clavulanic Acid tablet may be taken with or without it.
Side Effects
Cefuroxime-Clavulanic Acid is generally well tolerated. A few people may get nausea, vomiting, diarrhea, or abdominal discomfort or pain. As with other broad-spectrum antibiotics, taking the Cefuroxime and Clavulanic acid combination for a long time may let nonsusceptible microorganisms overgrow. Rarely (<0.2%), renal dysfunction, anaphylaxis, angioedema, pruritis, rash and serum sickness like urticaria may appear.
Cautions & Contraindications
Warnings & Precautions
Take care when giving cefuroxime to patients who are also being treated with potent diuretics, and to patients who have a history of colitis.
Contraindications
Don't give Cefuroxime-Clavulanic Acid to anyone who is known to be allergic to cephalosporins, or to anyone who has Pseudomembranous Colitis.
Pregnancy & Breastfeeding
Doctors try to avoid all antibiotics in the first trimester if they can. Cefuroxime-Clavulanic Acid, though, can be used safely in later pregnancy to treat urinary and other infections. A small amount of Cefuroxime-Clavulanic Acid passes into breast milk, and the possibility of sensitizing the infant should be kept in mind.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Cefuroxime Axetil + Clavulanic Acid in a cool, dry place, below 30°C, and away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Clavusef 125 mg+31.25 mg
What is Clavusef 125 mg+31.25 mg Tablet?
Clavusef 125 mg+31.25 mg Tablet is a medicine that contains Cefuroxime Axetil + Clavulanic Acid. It is made by Opsonin Pharma Limited. It belongs to the Second generation cephalosporins group of medicines.
What is Clavusef used for?
Clavusef is used for: Chronic Obstructive Pulmonary Disease, Bronchitis, Sinusitis, Pharyngitis, Tonsillitis, Bacterial Infection, Respiratory Tract Infection, Sepsis, Otitis Media.
What are the side effects of Clavusef?
Cefuroxime-Clavulanic Acid is generally well tolerated. A few people may get nausea, vomiting, diarrhea, or abdominal discomfort or pain.
Can I take Clavusef during pregnancy or while breastfeeding?
Doctors try to avoid all antibiotics in the first trimester if they can. Cefuroxime-Clavulanic Acid, though, can be used safely in later pregnancy to treat urinary and other infections. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Clavusef?
Keep Cefuroxime Axetil + Clavulanic Acid in a cool, dry place, below 30°C, and away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Clavusef?
Some medicines can interact with Cefuroxime Axetil + Clavulanic Acid, for example: Cefuroxime. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Clacef by OSL Pharma Ltd. has the same ingredient and strength for ৳18.00 per unit, compared with ৳20.00 for Clavusef. Ask your doctor or pharmacist before switching.
Do I need a prescription for Clavusef?
Clavusef is a prescription (Rx) medicine. Take it as your doctor advises.