Informational only — Not medical advice. Always consult a licensed healthcare provider.

Shasthya স্বাস্থ্য · Health, made simple
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Community data Updated 23 hours ago
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Indications

Respiratory Tract Infection Skin and Soft Tissue Infection Sepsis Otitis Media

Ceftriaxone Sodium injection is used to treat these major infections: lower respiratory tract infections, acute bacterial otitis media, skin and skin structure infections, urinary tract infections, gonorrhea, bacterial septicemia, bone and joint infections, and meningitis. It is also used for the prevention of postoperative infections and for perioperative prophylaxis of infections associated with surgery.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Ceftriaxone is a 3rd generation, broad-spectrum cephalosporin antibiotic that is given by injection. It kills a wide range of Gram-positive and Gram-negative bacteria. Like other cephalosporins and penicillins, Ceftriaxone works by interfering with the synthesis of the bacterial cell wall, and it stays stable in the presence of beta lactamases. One notable feature is its fairly long plasma elimination half-life of about 6 to 9 hours. Because of this, a single dose or a once-daily dose suits most patients. Ceftriaxone is not metabolized in the body. About 40-65% of a dose leaves unchanged in the urine. The rest is excreted in the bile and ends up in the feces as unchanged drug and a microbiologically inactive compound. The drug is highly protein bound (95%).

Pregnancy & Breastfeeding

Nobody has established that Ceftriaxone Sodium is safe in human pregnancy, so it shouldn't be used during pregnancy unless it is absolutely indicated. Ceftriaxone passes into human milk in low concentrations. Take caution when giving it to a breastfeeding mother.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: For adults, the usual dose of Ceftriaxone Sodium is 1 to 2 gm given by intravenous or intramuscular injection once a day, or as equally divided doses twice a day. This same dose of 1 to 2 g IV or IM once a day (or in equally divided doses twice a day) applies to pneumonia, bronchitis, acute bacterial otitis media, skin and skin structure infection, urinary tract infections, bacterial septicemia, bone and joint infections and meningitis. The maximum dose is 4 gm/day. Uncomplicated gonococcal infections: 250 mg IM as a single dose. Surgical prophylaxis: 1 g IV as a single dose, given 30 to 120 minutes before surgery. Infants and children (01 month or older): the usual dose is 50 to 75 mg/kg by intravenous or intramuscular injection once a day, or in equally divided doses twice a day. For pneumonia, bronchitis, skin and skin structure infection, urinary tract infections, bacterial septicemia and bone and joint infections, give 50 to 75 mg/kg IV or IM once a day (or in equally divided doses twice a day). The maximum dose is 2 gm/day. Acute bacterial otitis media: 50 mg/kg IM as a single dose. The maximum dose is 1 gm/day. Meningitis: 100 mg/kg IV or IM as a single daily dose (or in equally divided doses twice a day). The maximum dose is 4 gm/day. Duration of therapy: continue for more than 2 days after the signs and symptoms of infection have disappeared. The usual duration is 4 to 14 days, and in complicated infections longer therapy may be required.