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Indications & Uses
Prioxon is indicated for:
Pharmacology
Ceftriaxone is a 3rd generation, broad-spectrum cephalosporin antibiotic that is given by injection. It kills a wide range of Gram-positive and Gram-negative bacteria. Like other cephalosporins and penicillins, Ceftriaxone works by interfering with the synthesis of the bacterial cell wall, and it stays stable in the presence of beta lactamases. One notable feature is its fairly long plasma elimination half-life of about 6 to 9 hours. Because of this, a single dose or a once-daily dose suits most patients. Ceftriaxone is not metabolized in the body. About 40-65% of a dose leaves unchanged in the urine. The rest is excreted in the bile and ends up in the feces as unchanged drug and a microbiologically inactive compound. The drug is highly protein bound (95%).
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For adults, the usual dose of Ceftriaxone Sodium is 1 to 2 gm given by intravenous or intramuscular injection once a day, or as equally divided doses twice a day.
This same dose of 1 to 2 g IV or IM once a day (or in equally divided doses twice a day) applies to pneumonia, bronchitis, acute bacterial otitis media, skin and skin structure infection, urinary tract infections, bacterial septicemia, bone and joint infections and meningitis. The maximum dose is 4 gm/day.
Uncomplicated gonococcal infections: 250 mg IM as a single dose.
Surgical prophylaxis: 1 g IV as a single dose, given 30 to 120 minutes before surgery.
Infants and children (01 month or older): the usual dose is 50 to 75 mg/kg by intravenous or intramuscular injection once a day, or in equally divided doses twice a day.
For pneumonia, bronchitis, skin and skin structure infection, urinary tract infections, bacterial septicemia and bone and joint infections, give 50 to 75 mg/kg IV or IM once a day (or in equally divided doses twice a day). The maximum dose is 2 gm/day.
Acute bacterial otitis media: 50 mg/kg IM as a single dose. The maximum dose is 1 gm/day.
Meningitis: 100 mg/kg IV or IM as a single daily dose (or in equally divided doses twice a day). The maximum dose is 4 gm/day.
Duration of therapy: continue for more than 2 days after the signs and symptoms of infection have disappeared. The usual duration is 4 to 14 days, and in complicated infections longer therapy may be required.
Side Effects
Ceftriaxone Sodium is generally well tolerated, though a few side effects have been reported. In the gut, these include diarrhea, nausea and vomiting, stomatitis and glossitis. The skin can be affected too, with rash, pruritus, urticaria, edema and erythema multiforme. Blood-related reactions include eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia. In the liver, there may be elevations of SGOT or SGPT and bilirubinemia. Reactions involving the CNS include nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness. Local phlebitis is rare after intravenous administration, and giving the injection slowly over 2 to 4 minutes can reduce the chance of it.
Cautions & Contraindications
Warnings & Precautions
As with other cephalosporins, Ceftriaxone Sodium can cause anaphylactic shock, and taking a thorough patient history does not rule it out. If it happens, act at once with intravenous epinephrine, followed by a glucocorticoid. In rare cases, sonograms of the gallbladder have shown shadows that suggest sludge. This cleared up when Ceftriaxone Sodium therapy was stopped or completed. Even when these findings come with pain, conservative, nonsurgical management is recommended. If treatment goes on for a long time, the blood picture should be checked at regular intervals.
Contraindications
Don't give Ceftriaxone to anyone who has had a hypersensitivity reaction to cephalosporin antibiotics in the past.
Pregnancy & Breastfeeding
Nobody has established that Ceftriaxone Sodium is safe in human pregnancy, so it shouldn't be used during pregnancy unless it is absolutely indicated. Ceftriaxone passes into human milk in low concentrations. Take caution when giving it to a breastfeeding mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Ceftriaxone Sodium must not be given to newborn babies up to 28 days of age if they were born prematurely.
Overdose
Ceftriaxone Sodium has no specific antidote. If someone takes too much, the treatment is based on the symptoms.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store the Ceftriaxone Sodium vial in a cool, dry place below 30° C, and keep it away from light and moisture. Keep it out of the reach of children.
Common questions about Prioxon 500 mg
What is Prioxon 500 mg IV Injection?
Prioxon 500 mg IV Injection is a medicine that contains Ceftriaxone Sodium. It is made by DBL Pharmaceuticals Limited. It belongs to the Third generation cephalosporins group of medicines.
What is Prioxon used for?
Prioxon is used for: Respiratory Tract Infection, Skin and Soft Tissue Infection, Sepsis, Otitis Media.
What are the side effects of Prioxon?
Ceftriaxone Sodium is generally well tolerated, though a few side effects have been reported. In the gut, these include diarrhea, nausea and vomiting, stomatitis and glossitis.
Can I take Prioxon during pregnancy or while breastfeeding?
Nobody has established that Ceftriaxone Sodium is safe in human pregnancy, so it shouldn't be used during pregnancy unless it is absolutely indicated. Ceftriaxone passes into human milk in low concentrations. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Prioxon?
Ceftriaxone Sodium has no specific antidote. If someone takes too much, the treatment is based on the symptoms. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Prioxon?
Store the Ceftriaxone Sodium vial in a cool, dry place below 30° C, and keep it away from light and moisture. Keep it out of the reach of children.
Do I need a prescription for Prioxon?
Prioxon is a prescription (Rx) medicine. Take it as your doctor advises.