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Ceftazidime Pentahydrate

Third generation cephalosporins Prescription
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Indications

Pneumonia Respiratory Tract Infection Skin and Soft Tissue Infection Sepsis

Ceftazidime Pentahydrate Injection is used to treat infections caused by susceptible strains of the organisms named below, in the following diseases. For lower respiratory tract infections, including pneumonia, the organisms are Pseudomonas aeruginosa and other Pseudomonas spp., Haemophilus influenzae (including ampicillin-resistant strains), Klebsiella spp., Enterobacter spp., Proteus mirabilis, Escherichia coli, Serratia spp., Citrobacter spp., Streptococcus pneumoniae, and Staphylococcus aureus (methicillin susceptible strains). For skin and skin structure infections, they are Pseudomonas aeruginosa, Klebsiella spp., Escherichia coli, Proteus spp. (including Proteus mirabilis and indole-positive Proteus), Enterobacter spp., Serratia spp., Staphylococcus aureus (methicillin susceptible strains), and Streptococcus pyogenes (group A beta-hemolytic streptococci). Urinary tract infections, both complicated and uncomplicated, are covered when caused by Pseudomonas aeruginosa, Enterobacter spp., Proteus spp. (including Proteus mirabilis and indole-positive Proteus), Klebsiella spp., and Escherichia coli. Bacterial septicemia is covered when caused by Pseudomonas aeruginosa, Klebsiella spp., Haemophilus influenzae, Escherichia coli, Serratia spp., Streptococcus pneumoniae, and Staphylococcus aureus (methicillin susceptible strains). Bone and joint infections are covered when caused by Pseudomonas aeruginosa, Klebsiella spp., Enterobacter spp., and Staphylococcus aureus (methicillin susceptible strains). Gynecologic infections, including endometritis, pelvic cellulitis, and other infections of the female genital tract, are covered when caused by Escherichia coli. Intraabdominal infections, including peritonitis, are covered when caused by Escherichia coli, Klebsiella spp., and Staphylococcus aureus (methicillin susceptible strains), and so are polymicrobial infections caused by aerobic and anaerobic organisms and Bacteroides spp. Last, central nervous system infections, including meningitis, are covered when caused by Haemophilus influenzae, Neisseria meningitidis, Pseudomonas aeruginosa, and Streptococcus pneumoniae.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Ceftazidime is a semisynthetic, broad-spectrum beta-lactam antibiotic that is given by injection (parenteral administration). It kills bacteria, and it does this by blocking the enzymes that build the bacterial cell wall. In laboratory tests (in vitro), many gram-negative organisms are susceptible to ceftazidime, including strains that resist gentamicin and other aminoglycosides. It has also been shown to work against gram-positive organisms. Ceftazidime holds up well against most of the clinically important beta-lactamases, whether plasmid or chromosomal, which both gram-negative and gram-positive organisms produce. Because of this, it is active against many strains that resist ampicillin and other cephalosporins.

Pregnancy & Breastfeeding

Pregnancy: There have been no adequate and well-controlled studies of Ceftazidime in pregnant women. Animal reproduction studies don't always predict how humans will respond, so Ceftazidime should be used during pregnancy only if it is clearly needed.

Lactation: Ceftazidime passes into human milk in low concentrations. Many drugs pass into breast milk, and the safety of the components of the injections in nursing infants has not been established. So a decision should be made whether to stop nursing or to stop the drug, taking into account how important the drug is to the mother.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: The usual adult dose of ceftazidime is 1 gram, given into a vein or into a muscle every 8 to 12 hours. The dose and the route depend on how sensitive the causative organisms are, how severe the infection is, and the patient's condition and kidney function. Ceftazidime is used by the parenteral route only. The dose also varies with the type of infection and with the patient's age and weight. Adults: The dose range is 1 to 6 gm per day, given 8 or 12 hourly (IM/IV). For most infections, give 1 gm 8 hourly or 2 gm 12 hourly. Urinary tract infections and many less serious infections usually need only 500 mg or 1 gm 12 hourly. For severe infections, especially in immunocompromised patients and those with neutropenia, give 2 gm 8 or 12 hourly. As a prophylactic agent in prostatic surgery, give 1 gm at the induction of anesthesia. A second dose should be considered at the time of catheter removal. Infants and Children: For children over two months of age, the usual range is 30 to 100 mg/kg/day, divided into two or three doses. Doses up to 150 mg/kg/day (maximum 6 gm daily) may be given in three divided doses to infected immunocompromised or fibrocystic children, or to children with meningitis. Neonates and Children up to 2 months of age: The usual range is 25 to 60 mg/kg/day, given as two divided doses. Elderly: Clearance of ceftazidime is reduced in acutely ill elderly patients, so the daily dose should not normally exceed 3 gm, especially in those over 80 years of age. Cystic fibrosis: Fibrocystic adults with normal renal function who have pseudomonal lung infections should receive high doses of 100 to 150 mg/kg/day as three divided doses.