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Indications & Uses
Maxbac is indicated for:
Pharmacology
Ceftazidime is a semisynthetic, broad-spectrum beta-lactam antibiotic that is given by injection (parenteral administration). It kills bacteria, and it does this by blocking the enzymes that build the bacterial cell wall. In laboratory tests (in vitro), many gram-negative organisms are susceptible to ceftazidime, including strains that resist gentamicin and other aminoglycosides. It has also been shown to work against gram-positive organisms. Ceftazidime holds up well against most of the clinically important beta-lactamases, whether plasmid or chromosomal, which both gram-negative and gram-positive organisms produce. Because of this, it is active against many strains that resist ampicillin and other cephalosporins.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual adult dose of ceftazidime is 1 gram, given into a vein or into a muscle every 8 to 12 hours. The dose and the route depend on how sensitive the causative organisms are, how severe the infection is, and the patient's condition and kidney function. Ceftazidime is used by the parenteral route only. The dose also varies with the type of infection and with the patient's age and weight.
Adults: The dose range is 1 to 6 gm per day, given 8 or 12 hourly (IM/IV). For most infections, give 1 gm 8 hourly or 2 gm 12 hourly. Urinary tract infections and many less serious infections usually need only 500 mg or 1 gm 12 hourly. For severe infections, especially in immunocompromised patients and those with neutropenia, give 2 gm 8 or 12 hourly. As a prophylactic agent in prostatic surgery, give 1 gm at the induction of anesthesia. A second dose should be considered at the time of catheter removal.
Infants and Children: For children over two months of age, the usual range is 30 to 100 mg/kg/day, divided into two or three doses. Doses up to 150 mg/kg/day (maximum 6 gm daily) may be given in three divided doses to infected immunocompromised or fibrocystic children, or to children with meningitis.
Neonates and Children up to 2 months of age: The usual range is 25 to 60 mg/kg/day, given as two divided doses.
Elderly: Clearance of ceftazidime is reduced in acutely ill elderly patients, so the daily dose should not normally exceed 3 gm, especially in those over 80 years of age.
Cystic fibrosis: Fibrocystic adults with normal renal function who have pseudomonal lung infections should receive high doses of 100 to 150 mg/kg/day as three divided doses.
Side Effects
The commonest side effects of Ceftazidime Pentahydrate are local reactions after an IV injection, along with allergic and gastrointestinal reactions. The allergic (hypersensitivity) reactions are itching, rash and fever. Angioedema and anaphylaxis have been reported, but very rarely. Gastrointestinal symptoms include diarrhea, nausea, vomiting and abdominal pain. Reactions affecting the central nervous system included headache, dizziness and paresthesia.
Cautions & Contraindications
Warnings & Precautions
If a patient has kidney problems (renal insufficiency), the total daily dose of Ceftazidime Pentahydrate should be reduced. The medicine should also be prescribed with caution in people who have a history of gastrointestinal disease, particularly colitis.
Contraindications
Patients who have shown hypersensitivity to Ceftazidime, or to any antibiotic in the cephalosporin group, should not be given Ceftazidime.
Pregnancy & Breastfeeding
Pregnancy: There have been no adequate and well-controlled studies of Ceftazidime in pregnant women. Animal reproduction studies don't always predict how humans will respond, so Ceftazidime should be used during pregnancy only if it is clearly needed.
Lactation: Ceftazidime passes into human milk in low concentrations. Many drugs pass into breast milk, and the safety of the components of the injections in nursing infants has not been established. So a decision should be made whether to stop nursing or to stop the drug, taking into account how important the drug is to the mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Impaired renal function
The kidneys remove Ceftazidime Pentahydrate from the body, almost entirely by glomerular filtration. So in patients with impaired renal function (glomerular filtration rate <50 mL/min), it is recommended that the dose of ceftazidime be reduced, because the medicine leaves the body more slowly. If renal insufficiency is suspected, an initial loading dose of 1 gram of Ceftazidime Pentahydrate may be given. The GFR should then be estimated to decide the right maintenance dose.
Dosage in peritoneal dialysis
Ceftazidime Pentahydrate can also be used in peritoneal dialysis and continuous ambulatory peritoneal dialysis (CAPD). Besides giving it intravenously, it can be added to the dialysis fluid (usually 125 to 250 mg for 2L of dialysis fluid).
Impaired hepatic function
No change in dose is needed for patients with hepatic dysfunction.
Overdose
Overdose of Ceftazidime Pentahydrate has been seen in patients with renal failure. The reactions reported include seizure activity, encephalopathy, asterixis, neuromuscular excitability and coma. A patient who has taken an acute overdose should be watched carefully and given supportive treatment.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Ceftazidime Pentahydrate below 25°C, and protect it from light and moisture. Once it has been reconstituted, the solution stays stable for up to 24 h if you keep it between 2°C and 8°C.
Common questions about Maxbac 500 mg
What is Maxbac 500 mg IM/IV Injection?
Maxbac 500 mg IM/IV Injection is a medicine that contains Ceftazidime Pentahydrate. It is made by Rangs Pharmaceuticals Ltd. It belongs to the Third generation cephalosporins group of medicines.
What is Maxbac used for?
Maxbac is used for: Pneumonia, Respiratory Tract Infection, Skin and Soft Tissue Infection, Sepsis.
What are the side effects of Maxbac?
The commonest side effects of Ceftazidime Pentahydrate are local reactions after an IV injection, along with allergic and gastrointestinal reactions. The allergic (hypersensitivity) reactions are itching, rash and fever.
Can I take Maxbac during pregnancy or while breastfeeding?
Pregnancy: There have been no adequate and well-controlled studies of Ceftazidime in pregnant women. Animal reproduction studies don't always predict how humans will respond, so Ceftazidime should be used during pregnancy only if it is clearly needed. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Maxbac?
Overdose of Ceftazidime Pentahydrate has been seen in patients with renal failure. The reactions reported include seizure activity, encephalopathy, asterixis, neuromuscular excitability and coma. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Maxbac?
Keep Ceftazidime Pentahydrate below 25°C, and protect it from light and moisture. Once it has been reconstituted, the solution stays stable for up to 24 h if you keep it between 2°C and 8°C.
Do I need a prescription for Maxbac?
Maxbac is a prescription (Rx) medicine. Take it as your doctor advises.