Indications
Ceftaroline Fosamil is used to treat acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible isolates of these Gram positive and Gram negative microorganisms: Staphylococcus aureus (including methicillin-susceptible and resistant isolates), Streptococcus pyogenes, Streptococcus agalactiae, Escherichia coli, Klebsiella pneumoniae and Klebsiella oxytoca. It is also used for community-acquired bacterial pneumonia (CABP) caused by susceptible isolates of these Gram positive and Gram negative microorganisms: Streptococcus pneumoniae (including cases with concurrent bacteremia), Staphylococcus aureus, Haemophilus influenzae, Klebsiella pneumoniae, Klebsiella oxytoca and Escherichia coli.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Ceftaroline is a cephalosporin that works against both Gram-positive and Gram-negative bacteria. In vitro studies show it is bactericidal, meaning it kills the bacteria. It does this by binding to penicillin binding proteins (PBPs), which stops the bacteria from building their cell wall.
Ceftaroline is also active against methicillin-resistant Staphylococcus aureus (MRSA) and penicillin-nonsusceptible Streptococcus pneumoniae (PNSP). This is because it has an affinity for the altered PBPs found in these organisms.
Pregnancy & Breastfeeding
There's no clinical data on the use of Ceftaroline in pregnancy. Animal studies with Ceftaroline fosamil show no harmful effects on fertility, pregnancy, parturition or postnatal development. Even so, Ceftaroline should not be used during pregnancy unless it is clearly necessary and the possible benefit outweighs the possible risk.
Nobody knows whether Ceftaroline passes into human milk. Many beta-lactams do pass into breast milk, so women who are breast-feeding should be treated with Ceftaroline only if it is clearly indicated. Interruption of breast-feeding is recommended.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.