Pricing
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Zinforo is indicated for:
Pharmacology
Ceftaroline is a cephalosporin that works against both Gram-positive and Gram-negative bacteria. In vitro studies show it is bactericidal, meaning it kills the bacteria. It does this by binding to penicillin binding proteins (PBPs), which stops the bacteria from building their cell wall.
Ceftaroline is also active against methicillin-resistant Staphylococcus aureus (MRSA) and penicillin-nonsusceptible Streptococcus pneumoniae (PNSP). This is because it has an affinity for the altered PBPs found in these organisms.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Detailed dosing reference is not available yet. Please follow your prescription and consult your pharmacist.
Side Effects
Ceftaroline Fosamil most often causes diarrhea, nausea, vomiting, abdominal pain, headache, dizziness, rash and pruritus. Increased transaminases, phlebitis, pyrexia and infusion site reactions (erythema, phlebitis, pain) are also common. Less often, people may develop anemia, leucopenia, thrombocytopenia, hypersensitivity or anaphylaxis, urticaria, Clostridium difficile colitis, prolonged prothrombin time or increased blood creatinine. Eosinophilia is rare.
Cautions & Contraindications
Warnings & Precautions
Serious allergic (anaphylactic) reactions have been reported with beta-lactam antibacterial drugs, and Ceftaroline Fosamil is one of them. If a hypersensitivity reaction occurs, stop Ceftaroline Fosamil. Clostridium difficile-associated diarrhea (CDAD) has been reported with nearly all systemic antibacterial agents, Ceftaroline Fosamil included. If diarrhea occurs, it should be evaluated. Neurological adverse reactions have been reported in patients treated with cephalosporins, including Ceftaroline Fosamil. If they occur, consider stopping Ceftaroline Fosamil, or make suitable dosage adjustments in patients with renal impairment. If anemia develops during or after therapy, a diagnostic workup for drug-induced hemolytic anemia should be done, and stopping Ceftaroline Fosamil should be considered.
Contraindications
Don't give Ceftaroline Fosamil to anyone who is hypersensitive to the active substance or to any of the excipients in the product. It is also contraindicated in people who are hypersensitive to the cephalosporin class of antibacterials. The same applies if a person has had an immediate and severe hypersensitivity reaction (for example, an anaphylactic reaction) to any other type of beta-lactam antibacterial agent, such as penicillins or carbapenems.
Pregnancy & Breastfeeding
There's no clinical data on the use of Ceftaroline in pregnancy. Animal studies with Ceftaroline fosamil show no harmful effects on fertility, pregnancy, parturition or postnatal development. Even so, Ceftaroline should not be used during pregnancy unless it is clearly necessary and the possible benefit outweighs the possible risk.
Nobody knows whether Ceftaroline passes into human milk. Many beta-lactams do pass into breast milk, so women who are breast-feeding should be treated with Ceftaroline only if it is clearly indicated. Interruption of breast-feeding is recommended.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Use in pediatric patients: the safety and effectiveness of Ceftaroline Fosamil for treating ABSSSI have not been established in pediatric patients less than 34 weeks gestational age and less than 12 days postnatal age. For treating CABP, they have not been established in pediatric patients below the age of 2 months, because no data are available.
Renal impairment: adult patients with moderate (CrCl >30 to ≤50 ml/min) or severe (CrCl ≥15 to ≤30 ml/min) renal impairment need a dosage adjustment. The same applies to patients with end-stage renal disease (ESRD, defined as CrCl<15 ml/min), including those on hemodialysis (HD). For pediatric patients with CrCl <50 ml/min, there isn't enough information to recommend a dosage regimen.
Hepatic insufficiency: the pharmacokinetics of Ceftaroline Fosamil in patients with hepatic impairment have not been established. Ceftaroline Fosamil does not appear to undergo significant hepatic metabolism, so its systemic clearance is not expected to be significantly affected by hepatic impairment.
Overdose
Overdose with Ceftaroline Fosamil has been seen in patients with renal impairment. The reactions included neurological sequelae, among them encephalopathy. If an overdose happens, stop Ceftaroline Fosamil and give general supportive treatment.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Before it is reconstituted, keep Ceftaroline Fosamil powder for infusion at or below 30°C. Once it has been reconstituted, use it immediately. The diluted solution in the infusion bottle should be used within 6 hours if it is kept at room temperature, or within 24 hours if it is kept in a refrigerator at 2° to 8°C. Keep the medicine away from light and out of the reach of children.
Common questions about Zinforo 600 mg
What is Zinforo 600 mg IV Infusion?
Zinforo 600 mg IV Infusion is a medicine that contains Ceftaroline Fosamil. It is made by Radiant Pharmaceuticals Ltd. It belongs to the Fifth generation cephalosporins group of medicines.
What is Zinforo used for?
Zinforo is used for: Pneumonia, Skin and Soft Tissue Infection.
What are the side effects of Zinforo?
Ceftaroline Fosamil most often causes diarrhea, nausea, vomiting, abdominal pain, headache, dizziness, rash and pruritus. Increased transaminases, phlebitis, pyrexia and infusion site reactions (erythema, phlebitis, pain) are also common.
Can I take Zinforo during pregnancy or while breastfeeding?
There's no clinical data on the use of Ceftaroline in pregnancy. Animal studies with Ceftaroline fosamil show no harmful effects on fertility, pregnancy, parturition or postnatal development. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Zinforo?
Overdose with Ceftaroline Fosamil has been seen in patients with renal impairment. The reactions included neurological sequelae, among them encephalopathy. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Zinforo?
Before it is reconstituted, keep Ceftaroline Fosamil powder for infusion at or below 30°C. Once it has been reconstituted, use it immediately.
Do I need a prescription for Zinforo?
Zinforo is a prescription (Rx) medicine. Take it as your doctor advises.