Community data Updated 23 hours ago

Cefpodoxime Proxetil + Clavulanic Acid

Third generation cephalosporins Prescription

Indications

Chronic Obstructive Pulmonary Disease Pneumonia Bronchitis Sinusitis Pharyngitis Tonsillitis Skin and Soft Tissue Infection

Cefpodoxime Proxetil + Clavulanic Acid is indicated in these infections: acute bacterial exacerbation of chronic bronchitis, acute community acquired pneumonia, pharyngitis or tonsillitis, skin and soft tissue infections, urinary tract infections, uncomplicated gonorrhea, and acute maxillary sinusitis.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Cefpodoxime is a semi-synthetic, third generation cephalosporin. It works against several Gram positive and Gram negative microorganisms, and it stays stable in the presence of beta lactamase. Cefpodoxime is especially active against methicillin susceptible Staphylococci, Streptococcus pneumoniae, Haemophilus influenzae, Neisseria spp. and Moraxella catarrhalis.

Clavulanic acid is a natural beta lactamase inhibitor, produced by Streptomyces clavuligerus. It binds to beta lactamase moieties and inactivates them, so cefpodoxime is protected from being destroyed.

Pregnancy & Breastfeeding

Cefpodoxime and Clavulanic Acid falls under US FDA pregnancy category B. That said, there are no adequate and well-controlled studies in pregnant women. Animal reproduction studies don't always predict how a human will respond, so the medicine should be used during pregnancy only if it is clearly needed.

Cefpodoxime has been shown to pass into human milk. So caution should be exercised when Cefpodoxime is given to a nursing woman.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Adults aged 12 years and older take Cefpodoxime Proxetil + Clavulanic Acid in these doses. In acute bacterial exacerbation of chronic bronchitis, it's 1 tablet every 12 hours for 10 days. Acute community acquired pneumonia needs 1 tablet every 12 hours for 14 days. For pharyngitis or tonsillitis, the dose is ½ tablet every 12 hours for 5 to 10 days. Skin and soft tissue infections are treated with 2 tablets every 12 hours for 7 to 14 days, and urinary tract infections with ½ tablet every 12 hours for 7 days. Uncomplicated gonorrhea needs a single dose. In acute maxillary sinusitis, take 1 tablet every 12 hours for 10 days. Children from 2 months to 12 years get 10 mg/kg/day in divided doses, every 12 hours.

Side Effects & Interactions

Side Effects

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Key Interactions

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Cefpodoxime