Cefaclor Monohydrate

Adults: Capsule: The usual adult dose is 250 mg every 8 hours. For severe infections, or those caused by less susceptible organisms, the dose may be doubled, up to a maximum of 4 g/day. In β-hemolytic Streptococcal infections, therapy should be given for at least 10 days. Powder for suspension and Pediatric drops: For paediatric patients over 1 month, the usual daily dose is 20 mg/kg/day, given in divided doses every 8 hours. In serious infections such as otitis media, and in infections caused by less susceptible organisms, 40 mg/kg/day is recommended, with a maximum of 1 g/day. Safety and effectiveness of Cefaclor in infants less than 1 month of age have not been established. Under 1 year (9 kg): Powder for suspension, ½ tsp three times daily. Pediatric drops, 0.625 ml three times daily. For 1 to 5 years (9 kg to 18 kg): Powder for suspension, 1 tsp three times daily. Pediatric drops, 1.25 ml three times daily. Over 5 years: Powder for suspension, 2 tsp three times daily. In renal impairment: Cefaclor may be given when kidney function is impaired. Dose adjustment is not usually required for patients with moderate or severe renal impairment. In patients undergoing haemodialysis: Haemodialysis shortens the serum half-life by 25 to 30%. For these patients, a predialysis loading dose of 250 mg to 1 g is recommended. A maintaining dose of 250 to 500 mg every 6 hours may be used during the interdialytic period. Geriatric use: Clinical experience hasn't shown any difference in response between elderly and younger patients, but greater sensitivity in some older people can't be ruled out.