Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 2 months ago

Indications

Vesodil is used to treat mild, moderate or severe heart failure caused by ischaemic heart disease or cardiomyopathy. It is given together with digitalis, diuretics and an ACE inhibitor to slow the progression of the disease, as measured by cardiovascular death, hospital admission for cardiovascular causes, or the need to adjust other heart failure medicines. Vesodil may be used in patients who cannot tolerate an ACE inhibitor. It may also be used in patients who are not receiving digitalis, hydralazine or nitrate therapy.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Carvedilol is a heart and blood pressure medicine. Its main effect comes from non-selective blockade of β-adrenergic receptors, though it also blocks α-adrenergic receptors to a meaningful extent. Beyond this, it has antiproliferative effects and helps mop up harmful reactive oxygen free radicals. It is used to treat high blood pressure, angina (chest pain from reduced blood flow to the heart), and congestive heart failure.

Pregnancy & Breastfeeding

Carvedilol should not be used while breastfeeding. No studies have been done in women who are breastfeeding, and animal studies have shown that carvedilol passes into breast milk. Its safety and effectiveness in children have not been established either. Carvedilol should also not be used during pregnancy, as no studies have been carried out in pregnant women. Animal studies have shown that carvedilol crosses the placenta. There is no information on whether carvedilol is safe or effective for newborn babies.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Hypertension: start with 12.5 mg once daily, increased after 2 days to the usual dose of 25 mg once daily. If needed, the dose may be raised further at intervals of at least 2 weeks, up to a maximum of 50 mg daily taken as a single dose or in divided doses. In elderly patients, a starting dose of 12.5 mg daily may give satisfactory control. Angina pectoris: the recommended starting dose is 12.5 mg twice daily for the first 2 days. After that, the recommended dose is 25 mg twice daily. For elderly patients, the maximum is 50 mg daily in divided doses. Heart failure: start with 3.125 mg twice daily, taken with food. The dose may be increased at intervals of at least 2 weeks to 6.25 mg twice daily, then to 12.5 mg twice daily, and then to 25 mg twice daily. The dose may be raised to the highest dose tolerated, up to a maximum of 25 mg twice daily in patients weighing less than 85 kg and 50 mg twice daily in patients weighing more than 85 kg.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.