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Other brands with the same active ingredient
These brands contain the same active ingredient (Carvedilol). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Durol
Other strengths and forms by Square Pharmaceuticals PLC, Pabna
Indications & Uses
Durol is indicated for:
Pharmacology
Carvedilol is a heart and blood pressure medicine. Its main effect comes from non-selective blockade of β-adrenergic receptors, though it also blocks α-adrenergic receptors to a meaningful extent. Beyond this, it has antiproliferative effects and helps mop up harmful reactive oxygen free radicals. It is used to treat high blood pressure, angina (chest pain from reduced blood flow to the heart), and congestive heart failure.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Hypertension: start with 12.5 mg once daily, increased after 2 days to the usual dose of 25 mg once daily. If needed, the dose may be raised further at intervals of at least 2 weeks, up to a maximum of 50 mg daily taken as a single dose or in divided doses. In elderly patients, a starting dose of 12.5 mg daily may give satisfactory control.
Angina pectoris: the recommended starting dose is 12.5 mg twice daily for the first 2 days. After that, the recommended dose is 25 mg twice daily. For elderly patients, the maximum is 50 mg daily in divided doses.
Heart failure: start with 3.125 mg twice daily, taken with food. The dose may be increased at intervals of at least 2 weeks to 6.25 mg twice daily, then to 12.5 mg twice daily, and then to 25 mg twice daily. The dose may be raised to the highest dose tolerated, up to a maximum of 25 mg twice daily in patients weighing less than 85 kg and 50 mg twice daily in patients weighing more than 85 kg.
Side Effects
Common side effects include a drop in blood pressure on standing (postural hypotension), dizziness, headache, tiredness, stomach or bowel upset, and a slow heart rate (bradycardia). Occasionally, patients may experience reduced blood flow to the hands and feet, swelling of the limbs (peripheral oedema) with painful extremities, dry mouth, dry eyes, eye irritation or blurred or disturbed vision, impotence, difficulty passing urine, and flu-like symptoms. Rarely reported effects include angina, AV block (a disturbance of the heart's electrical conduction), worsening of intermittent claudication (leg pain on walking) or Raynaud's phenomenon, allergic skin reactions, worsening of psoriasis, a blocked nose, wheezing, low mood, sleep disturbances, tingling or numbness (paresthesia), heart failure, changes in liver enzyme levels, and reduced platelet or white blood cell counts (thrombocytopenia, leukopenia).
Cautions & Contraindications
Warnings & Precautions
Use carvedilol with caution in hepatic impairment. In heart failure, monitor the patient's clinical status for 2 to 3 hours after the first dose and after each dose increase. Before increasing the dose, confirm that kidney function and the heart failure are not getting worse.
Contraindications
Carvedilol must not be used in patients with decompensated heart failure who need intravenous inotropic therapy, bronchial asthma or related bronchospastic conditions, second- or third-degree AV block, sick sinus syndrome (unless a permanent pacemaker is in place), cardiogenic shock, or severe bradycardia.
Pregnancy & Breastfeeding
Carvedilol should not be used while breastfeeding. No studies have been done in women who are breastfeeding, and animal studies have shown that carvedilol passes into breast milk. Its safety and effectiveness in children have not been established either. Carvedilol should also not be used during pregnancy, as no studies have been carried out in pregnant women. Animal studies have shown that carvedilol crosses the placenta. There is no information on whether carvedilol is safe or effective for newborn babies.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Carvedilol below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Durol 25 mg
What is Durol 25 mg Tablet?
Durol 25 mg Tablet is a medicine that contains Carvedilol. It is made by Square Pharmaceuticals PLC, Pabna. It belongs to the Alpha adrenoceptor blocking drugs group of medicines.
What is Durol used for?
Durol is used for: Heart Failure.
What are the side effects of Durol?
Common side effects include a drop in blood pressure on standing (postural hypotension), dizziness, headache, tiredness, stomach or bowel upset, and a slow heart rate (bradycardia). Occasionally, patients may experience reduced blood flow to the hands and feet, swelling of the limbs (peripheral oedema) with painful extremities, dry mouth, dry eyes, eye irritation or blurred or disturbed vision, impotence, difficulty passing urine, and flu-like symptoms.
Can I take Durol during pregnancy or while breastfeeding?
Carvedilol should not be used while breastfeeding. No studies have been done in women who are breastfeeding, and animal studies have shown that carvedilol passes into breast milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Durol?
Store Carvedilol below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Durol?
Some medicines can interact with Carvedilol, for example: Talazoparib, Digoxin, Ravuconazole, Clonidine Hydrochloride, Filgotinib Maleate. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Durol?
Durol is a prescription (Rx) medicine. Take it as your doctor advises.