Informational only — Not medical advice. Always consult a licensed healthcare provider.

Shasthya স্বাস্থ্য · Health, made simple
বাং
Community data Updated 23 hours ago

Cariprazine

Prescription
Check interactions
🌐 বাংলায় দেখুন

Indications

Depression Schizophrenia

Cariprazine is an atypical antipsychotic. It is used in adults for the treatment of schizophrenia, for the acute treatment of manic or mixed episodes associated with bipolar I disorder, and for the treatment of depressive episodes associated with bipolar I disorder (bipolar depression). It is also used as adjunctive therapy to antidepressants for the treatment of major depressive disorder (MDD) in adults.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

No one knows how cariprazine works. Its effect may come from a mix of actions in the brain: partial agonist activity at central dopamine D2 and serotonin 5-HT1A receptors, and antagonist activity at serotonin 5-HT2A receptors. In the body, cariprazine forms two major metabolites, desmethylcariprazine (DCAR) and didesmethylcariprazine (DDCAR). In vitro, both bind to receptors in a pattern similar to cariprazine itself.

Pregnancy & Breastfeeding

A pregnancy exposure registry follows the outcomes of pregnancies in women who took Cariprazine while pregnant. As for breastfeeding, no lactation studies have been done on cariprazine. So it isn't known whether the medicine passes into human milk, what effect it may have on a breastfed infant, or whether it changes milk production.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: General Dosing Information Cariprazine is taken by mouth once a day, with or without food. The medicine and its active metabolites stay in the body for a long time, so a change in dose won't show fully in plasma for several weeks. Prescribers should watch patients for adverse reactions and for how well the treatment is working, for several weeks after starting Cariprazine and again after each dosage change. Recommended Dosage in Schizophrenia The starting dosage of Cariprazine is 1.5 mg once daily, and the recommended range is 1.5 mg to 6 mg once daily. The dose can go up to 3 mg on Day 2. After that, depending on clinical response and how well the patient tolerates it, further adjustments can be made in steps of 1.5 mg or 3 mg. The maximum recommended dosage is 6 mg daily. In short-term controlled trials, dosages above 6 mg daily did not give enough extra benefit to outweigh the dose-related adverse reactions. Recommended Dosage in Manic or Mixed Episodes Associated with Bipolar I Disorder Here too the starting dosage of Cariprazine is 1.5 mg once daily, and it should be raised to 3 mg once daily on Day 2. The recommended range is 3 mg to 6 mg once daily. Depending on clinical response and tolerability, further adjustments can be made in steps of 1.5 mg or 3 mg. The maximum recommended dosage is 6 mg daily. As in schizophrenia, short-term controlled trials showed that dosages above 6 mg daily did not give enough extra benefit to outweigh the dose-related adverse reactions. Recommended Dosage in Depressive Episodes Associated with Bipolar I Disorder (Bipolar Depression) The starting dosage of Cariprazine is 1.5 mg once daily. Depending on clinical response and tolerability, the dosage can be increased to 3 mg once daily on Day 15. The maximum recommended dosage is 3 mg once daily. Recommended Dosage for Adjunctive Therapy to Antidepressants for the Treatment of Major Depressive Disorder The starting dosage of Cariprazine is 1.5 mg once daily. Depending on clinical response and tolerability, the dosage can be increased to 3 mg once daily on Day 15. In clinical trials, increasing the dose at intervals of less than 14 days led to a higher rate of adverse reactions. The maximum recommended dosage is 3 mg once daily.