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Indications & Uses
Caripran is indicated for:
Pharmacology
No one knows how cariprazine works. Its effect may come from a mix of actions in the brain: partial agonist activity at central dopamine D2 and serotonin 5-HT1A receptors, and antagonist activity at serotonin 5-HT2A receptors. In the body, cariprazine forms two major metabolites, desmethylcariprazine (DCAR) and didesmethylcariprazine (DDCAR). In vitro, both bind to receptors in a pattern similar to cariprazine itself.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
General Dosing Information
Cariprazine is taken by mouth once a day, with or without food. The medicine and its active metabolites stay in the body for a long time, so a change in dose won't show fully in plasma for several weeks. Prescribers should watch patients for adverse reactions and for how well the treatment is working, for several weeks after starting Cariprazine and again after each dosage change.
Recommended Dosage in Schizophrenia
The starting dosage of Cariprazine is 1.5 mg once daily, and the recommended range is 1.5 mg to 6 mg once daily. The dose can go up to 3 mg on Day 2. After that, depending on clinical response and how well the patient tolerates it, further adjustments can be made in steps of 1.5 mg or 3 mg. The maximum recommended dosage is 6 mg daily. In short-term controlled trials, dosages above 6 mg daily did not give enough extra benefit to outweigh the dose-related adverse reactions.
Recommended Dosage in Manic or Mixed Episodes Associated with Bipolar I Disorder
Here too the starting dosage of Cariprazine is 1.5 mg once daily, and it should be raised to 3 mg once daily on Day 2. The recommended range is 3 mg to 6 mg once daily. Depending on clinical response and tolerability, further adjustments can be made in steps of 1.5 mg or 3 mg. The maximum recommended dosage is 6 mg daily. As in schizophrenia, short-term controlled trials showed that dosages above 6 mg daily did not give enough extra benefit to outweigh the dose-related adverse reactions.
Recommended Dosage in Depressive Episodes Associated with Bipolar I Disorder (Bipolar Depression)
The starting dosage of Cariprazine is 1.5 mg once daily. Depending on clinical response and tolerability, the dosage can be increased to 3 mg once daily on Day 15. The maximum recommended dosage is 3 mg once daily.
Recommended Dosage for Adjunctive Therapy to Antidepressants for the Treatment of Major Depressive Disorder
The starting dosage of Cariprazine is 1.5 mg once daily. Depending on clinical response and tolerability, the dosage can be increased to 3 mg once daily on Day 15. In clinical trials, increasing the dose at intervals of less than 14 days led to a higher rate of adverse reactions. The maximum recommended dosage is 3 mg once daily.
Side Effects
The most common side effects of cariprazine were those that occurred in 5% or more of people and at least twice as often as with placebo. In schizophrenia, these were extrapyramidal symptoms and akathisia. In bipolar mania, the list was extrapyramidal symptoms, akathisia, dyspepsia, vomiting, somnolence and restlessness. For bipolar depression, people reported nausea, akathisia, restlessness and extrapyramidal symptoms. When cariprazine was used as adjunctive treatment of MDD, the common ones were akathisia, restlessness, fatigue, constipation, nausea, insomnia, increased appetite, dizziness and extrapyramidal symptoms.
Cautions & Contraindications
Warnings & Precautions
In elderly patients with dementia-related psychosis, Cariprazine is linked with a higher incidence of cerebrovascular adverse reactions (e.g., stroke, transient ischemic attack). Neuroleptic malignant syndrome is managed by stopping the medicine immediately and monitoring the patient closely. With tardive dyskinesia, discontinue if appropriate. Late-occurring adverse reactions are possible because of the long half-life of Cariprazine. Monitor for adverse reactions and for the patient's response for several weeks after starting it, and again with each dosage change. For metabolic changes, monitor for hyperglycemia/diabetes mellitus, dyslipidemia and weight gain. Leukopenia, neutropenia and agranulocytosis need attention too. Perform complete blood counts (CBC) in patients with pre-existing low white blood cell counts (WBC) or a history of leukopenia or neutropenia. Consider discontinuing the medicine if a clinically significant decline in WBC occurs and there are no other causative factors. Orthostatic hypotension and syncope: monitor heart rate and blood pressure. Warn patients with known cardiovascular or cerebrovascular disease, and those at risk of dehydration or syncope. Seizures: use cautiously in patients with a history of seizures or with conditions that lower the seizure threshold. There is a potential for cognitive and motor impairment, so use caution when operating machinery.
Contraindications
Cariprazine must not be given to anyone who has had a hypersensitivity reaction to cariprazine before. These reactions have included rash, pruritus and urticaria. Some have looked like angioedema, with a swollen tongue, lip swelling, face edema, pharyngeal edema and swelling of the face.
Pregnancy & Breastfeeding
A pregnancy exposure registry follows the outcomes of pregnancies in women who took Cariprazine while pregnant. As for breastfeeding, no lactation studies have been done on cariprazine. So it isn't known whether the medicine passes into human milk, what effect it may have on a breastfed infant, or whether it changes milk production.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric Use
The safety and effectiveness of Cariprazine in pediatric patients have not been established, and no pediatric studies of Cariprazine have been conducted. Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric patients.
Geriatric Use
Clinical trials of Cariprazine did not include enough patients aged 65 and older to show whether they respond differently from younger patients. In general, the dose for an elderly patient should be chosen with care, usually starting at the low end of the dosing range. This is because decreased liver, kidney or heart function is more common in older people, and so are other diseases and other drug therapy.
Storage
Store Cariprazine below 30°C, away from light and moisture. Keep it out of the reach of children.
Common questions about Caripran 3 mg
What is Caripran 3 mg Capsule?
Caripran 3 mg Capsule is a medicine that contains Cariprazine. It is made by Incepta Pharmaceuticals Ltd.
What is Caripran used for?
Caripran is used for: Depression, Schizophrenia.
What are the side effects of Caripran?
The most common side effects of cariprazine were those that occurred in 5% or more of people and at least twice as often as with placebo. In schizophrenia, these were extrapyramidal symptoms and akathisia.
Can I take Caripran during pregnancy or while breastfeeding?
A pregnancy exposure registry follows the outcomes of pregnancies in women who took Cariprazine while pregnant. As for breastfeeding, no lactation studies have been done on cariprazine. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Caripran?
Store Cariprazine below 30°C, away from light and moisture. Keep it out of the reach of children.
Is there a cheaper medicine with the same ingredient?
Caripran is already among the lowest-priced brands of Cariprazine at this strength.
Do I need a prescription for Caripran?
Caripran is a prescription (Rx) medicine. Take it as your doctor advises.