Indications
Calcipotriol Monohydrate is applied to the skin to treat chronic stable plaque type psoriasis vulgaris in adults.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Calcipotriol is a non-steroidal antipsoriatic agent made from vitamin D. It acts like vitamin D by competing for the 1,25(OH)2D3 receptor. In regulating cell proliferation and cell differentiation, calcipotriol is as potent as 1,25(OH)2D3, the active form of vitamin D that occurs naturally in the body. Its effect on calcium metabolism, though, is much weaker than that of 1,25(OH)2D3.
In keratinocytes, calcipotriol induces differentiation and suppresses proliferation, and there is no evidence of a cytotoxic effect. This reverses the abnormal keratinocyte changes seen in psoriasis. So the therapeutic goal with calcipotriol is a normalization of epidermal growth.
Pregnancy & Breastfeeding
Nobody has established that calcipotriol is safe in pregnancy, so it should not be used during pregnancy unless the benefits clearly outweigh the risks. During breastfeeding the position is similar. It isn't known whether calcipotriol passes into breast milk, so the medicine should be used while breastfeeding only if the benefits clearly outweigh the risks. Mothers should also not apply calcipotriol to the chest area while breastfeeding, because the infant could swallow it.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.