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Indications & Uses
Calcipotriol Monohydrate is applied to the skin to treat chronic stable plaque type psoriasis vulgaris in adults.
Pharmacology
Calcipotriol is a non-steroidal antipsoriatic agent made from vitamin D. It acts like vitamin D by competing for the 1,25(OH)2D3 receptor. In regulating cell proliferation and cell differentiation, calcipotriol is as potent as 1,25(OH)2D3, the active form of vitamin D that occurs naturally in the body. Its effect on calcium metabolism, though, is much weaker than that of 1,25(OH)2D3.
In keratinocytes, calcipotriol induces differentiation and suppresses proliferation, and there is no evidence of a cytotoxic effect. This reverses the abnormal keratinocyte changes seen in psoriasis. So the therapeutic goal with calcipotriol is a normalization of epidermal growth.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Calcipotriol cream and ointment are applied to the affected area twice a day, once in the morning and once in the evening. After the first period of treatment, the doctor may suggest applying it less often. Once the skin has improved satisfactorily, stop the treatment. If the problem comes back after stopping, treatment can be started again. There is little experience of using calcipotriol for longer than 1 year. For calcipotriol cream, the maximum recommended dose is 100 gm per week.
Side Effects
Reports of side effects with topical calcipotriol include photosensitivity reactions, skin discolouration, bullous eruption, skin exfoliation, contact dermatitis and allergic reactions.
Cautions & Contraindications
Warnings & Precautions
Calcipotriol Monohydrate cream and ointment isn't recommended for people with generalized pustular psoriasis, guttate psoriasis or erythrodermic exfoliate psoriasis. It also shouldn't be used on the face.
Contraindications
Calcipotriol cream and ointment must not be used by patients who have a history of hypersensitivity to any component of the preparations. They are also contraindicated in patients with known disorders of calcium metabolism.
Pregnancy & Breastfeeding
Nobody has established that calcipotriol is safe in pregnancy, so it should not be used during pregnancy unless the benefits clearly outweigh the risks. During breastfeeding the position is similar. It isn't known whether calcipotriol passes into breast milk, so the medicine should be used while breastfeeding only if the benefits clearly outweigh the risks. Mothers should also not apply calcipotriol to the chest area while breastfeeding, because the infant could swallow it.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Calcipotriol Monohydrate cream and ointment should not be used in children, because there isn't enough experience with its use in this age group.
Storage
Keep Calcipotriol Monohydrate below 25° C, and away from light and moisture. Don't let it freeze. As with all medicines, keep it out of reach of children.
Common questions about Planex 0.005%
What is Planex 0.005% Ointment?
Planex 0.005% Ointment is a medicine that contains Calcipotriol Monohydrate. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Topical Vitamin D & related preparations group of medicines.
What is Planex used for?
Calcipotriol Monohydrate is applied to the skin to treat chronic stable plaque type psoriasis vulgaris in adults.
What are the side effects of Planex?
Reports of side effects with topical calcipotriol include photosensitivity reactions, skin discolouration, bullous eruption, skin exfoliation, contact dermatitis and allergic reactions.
Can I take Planex during pregnancy or while breastfeeding?
Nobody has established that calcipotriol is safe in pregnancy, so it should not be used during pregnancy unless the benefits clearly outweigh the risks. During breastfeeding the position is similar. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Planex?
Keep Calcipotriol Monohydrate below 25° C, and away from light and moisture. Don't let it freeze.
Do I need a prescription for Planex?
Planex is a prescription (Rx) medicine. Take it as your doctor advises.