Indications
Cabazitaxel is used together with prednisone or prednisolone in patients with hormone refractory metastatic prostate cancer who have already been treated with a regimen containing docetaxel. Neutropenia is common with this medicine, so granulocyte-colony stimulating factor (G-CSF) should be given within 24 to 72 hr of starting the 1st cycle of Cabazitaxel.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Cabazitaxel is a microtubule inhibitor. It binds to tubulin and pushes it to assemble into microtubules, while at the same time stopping those microtubules from breaking down. The microtubules become stabilised as a result, and this interferes with the cell's mitotic and interphase functions. The cell can't move further through the cell cycle and stalls at metaphase, which triggers apoptosis of the cancer cell.
Pregnancy & Breastfeeding
Cabazitaxel is in pregnancy category D. This means there is positive evidence of risk to the human foetus. Even so, a doctor may accept that risk if the benefit to the pregnant woman is worth it, for example when the medicine is needed in a life-threatening situation or for a serious disease where safer drugs can't be used or don't work.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.