Pricing
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All price changes →Indications & Uses
Jevtana is indicated for:
Pharmacology
Cabazitaxel is a microtubule inhibitor. It binds to tubulin and pushes it to assemble into microtubules, while at the same time stopping those microtubules from breaking down. The microtubules become stabilised as a result, and this interferes with the cell's mitotic and interphase functions. The cell can't move further through the cell cycle and stalls at metaphase, which triggers apoptosis of the cancer cell.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults are given cabazitaxel at 25 mg/m2 as an IV infusion over 1 hr, repeated every 3 wk. It is used together with oral prednisone or prednisolone 10 mg, which the patient takes daily throughout treatment.
Side Effects
With cabazitaxel, the side effects seen most often at any grade are anemia, leukopenia, neutropenia, thrombocytopenia and diarrhea. When you look only at grade 3 or higher, the most common ones are neutropenia, leukopenia, anemia, febrile neutropenia and diarrhea.
Cautions & Contraindications
Warnings & Precautions
Take care with Cabazitaxel in people who have a hypersensitivity reaction, neutropenia, nausea, vomiting, diarrhea, dehydration or peripheral neuropathy. The same care applies to renal failure, cardiac arrhythmias, liver impairment and anemia. Pregnancy and lactation need caution, and so does use in the elderly.
Contraindications
Cabazitaxel must not be used when neutrophil counts are below 1,500/mm3, platelets are above 100,000/mm3, haemoglobin is above 10 g/dL, or creatinine is below 1.5 x ULN. It is also not for people with hepatic impairment (bilirubin ≥1 x ULN, or AST and/or ALT ≥1.5 × ULN), or those having the yellow fever vaccine at the same time.
Pregnancy & Breastfeeding
Cabazitaxel is in pregnancy category D. This means there is positive evidence of risk to the human foetus. Even so, a doctor may accept that risk if the benefit to the pregnant woman is worth it, for example when the medicine is needed in a life-threatening situation or for a serious disease where safer drugs can't be used or don't work.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Children
The safety and efficacy of Cabazitaxel in children have not been established.
Elderly
No specific dose adjustment is recommended when Cabazitaxel is used in elderly patients (see Pharmacology: Pharmacokinetics under Actions, Precautions and Adverse Reactions).
Hepatic Impairment
The liver metabolizes Cabazitaxel extensively. In patients with mild hepatic impairment [total bilirubin >1 to ≤1.5 x Upper Limit of Normal (ULN) or AST >1.5 x ULN], the dose should be reduced to 20 mg/m2. Give Cabazitaxel with caution to these patients and monitor their safety closely. For moderate hepatic impairment (total bilirubin >1.5 to ≤3.0 x ULN), 15 mg/m2 is the maximum tolerated dose, but the efficacy data available at this dose are too limited to recommend it in this population. Cabazitaxel should not be given to patients with severe hepatic impairment (total bilirubin >3 x ULN).
Renal Impairment
The kidney excretes very little Cabazitaxel, so no dose adjustment is necessary in patients with renal impairment who don't need hemodialysis. Patients with end-stage renal disease (CLCR <15 mL/min/1.73 m2) should be treated with caution and monitored carefully during treatment, because of their condition and the limited data available.
Concomitant Drug Use
Avoid medicines that are strong CYP3A inducers or strong CYP3A inhibitors (see Pharmacology: Pharmacokinetics under Actions and Interactions). If a patient does need a strong CYP3A inhibitor given together with Cabazitaxel, a 25% dose reduction of Cabazitaxel should be considered (see Pharmacology: Pharmacokinetics under Actions and Interactions).
Storage
Keep Cabazitaxel at 15 to 30° C. Don't put it in the refrigerator.
Common questions about Jevtana 60 mg/1.5 ml
What is Jevtana 60 mg/1.5 ml IV Infusion?
Jevtana 60 mg/1.5 ml IV Infusion is a medicine that contains Cabazitaxel. It is made by Synovia Pharma PLC. It belongs to the Cytotoxic Chemotherapy group of medicines.
What is Jevtana used for?
Jevtana is used for: Cancer.
What are the side effects of Jevtana?
With cabazitaxel, the side effects seen most often at any grade are anemia, leukopenia, neutropenia, thrombocytopenia and diarrhea. When you look only at grade 3 or higher, the most common ones are neutropenia, leukopenia, anemia, febrile neutropenia and diarrhea.
Can I take Jevtana during pregnancy or while breastfeeding?
Cabazitaxel is in pregnancy category D. This means there is positive evidence of risk to the human foetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Jevtana?
Keep Cabazitaxel at 15 to 30° C. Don't put it in the refrigerator.
Do I need a prescription for Jevtana?
Jevtana is a prescription (Rx) medicine. Take it as your doctor advises.