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Community data Updated 23 hours ago

Bupropion Hydrochloride

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Indications

Depression

Bupropion Hydrochloride is used to treat depression. Doctors also prescribe it to help people stop smoking.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Bupropion selectively blocks the re-uptake of catecholamines (noradrenaline and dopamine) in neurons. It has minimal effect on the re-uptake of indolamines (serotonin), and it does not inhibit monoamine oxidase. Like other antidepressants, its exact mechanism of action is unknown, but the effect is presumed to come from noradrenergic and/or dopaminergic mechanisms.

Pregnancy & Breastfeeding

Bupropion is Pregnancy Category C. There are no adequate and well controlled studies in pregnant women, so the medicine should be used during pregnancy only if it is clearly needed.

Bupropion and its metabolites pass into human milk. Because of this, a decision has to be made whether to stop breast feeding or to stop the medicine.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: The usual adult target dose of Bupropion is 300 mg/day, given as 150 mg twice daily. Treatment should begin at 150 mg/day, taken as a single dose in the morning. If the patient tolerates this starting dose well enough, the dose may be raised to the 300 mg/day target (150 mg twice daily) as early as day 4. Leave an interval of at least 8 hours between doses. Increasing the dosage above 300 mg/day As with other antidepressants, the full effect of Bupropion Hydrochloride may not show until 4 weeks of treatment or longer. For patients who have had no clinical improvement after several weeks at 300 mg/day, an increase to the maximum of 400 mg/day, given as 200 mg twice daily, may be considered. Bupropion Hydrochloride should be stopped in patients who don't show an adequate response after an appropriate period of treatment at 450 mg/day. Maintenance The lowest dose that keeps the patient in remission is recommended. Nobody knows exactly how long a patient should stay on Bupropion Hydrochloride, but it is generally recognised that acute episodes of depression need several months or longer of antidepressant treatment. Child and adolescent Not recommended for children and adolescents under 18 years of age.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.