Indications
Bisoprolol Fumarate + Amlodipine Besilate tablet is used to treat hypertension (high blood pressure). It is meant as a substitute for patients whose blood pressure is already well controlled on bisoprolol and amlodipine taken together as separate tablets, at the same doses as in this combination tablet.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Amlodipine is a dihydropyridine calcium antagonist. It blocks calcium ions from moving across the cell membrane into vascular smooth muscle and cardiac muscle. Both kinds of muscle need extracellular calcium to enter through specific ion channels before they can contract. Amlodipine blocks this entry selectively, and its effect is greater on vascular smooth muscle cells than on cardiac muscle cells. It acts directly on the blood vessels, which lowers peripheral vascular resistance and so lowers blood pressure.
Bisoprolol Fumarate is a synthetic, beta1-selective (cardioselective) adrenoceptor blocking agent. It has no intrinsic sympathomimetic activity and no relevant membrane stabilizing activity. Its affinity is low for the beta2 receptors of the smooth muscles of the bronchi and vessels, and also for the beta2-receptors involved in metabolic regulation. For this reason, bisoprolol is generally not expected to affect airway resistance or beta2-mediated metabolic effects. Its beta1-selectivity extends beyond the therapeutic dose range.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.