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Same active ingredient — pay up to 31% less
These brands contain the same active ingredient (Bisoprolol Fumarate + Amlodipine Besilate). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Bisocam is indicated for:
Pharmacology
Amlodipine is a dihydropyridine calcium antagonist. It blocks calcium ions from moving across the cell membrane into vascular smooth muscle and cardiac muscle. Both kinds of muscle need extracellular calcium to enter through specific ion channels before they can contract. Amlodipine blocks this entry selectively, and its effect is greater on vascular smooth muscle cells than on cardiac muscle cells. It acts directly on the blood vessels, which lowers peripheral vascular resistance and so lowers blood pressure.
Bisoprolol Fumarate is a synthetic, beta1-selective (cardioselective) adrenoceptor blocking agent. It has no intrinsic sympathomimetic activity and no relevant membrane stabilizing activity. Its affinity is low for the beta2 receptors of the smooth muscles of the bronchi and vessels, and also for the beta2-receptors involved in metabolic regulation. For this reason, bisoprolol is generally not expected to affect airway resistance or beta2-mediated metabolic effects. Its beta1-selectivity extends beyond the therapeutic dose range.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults can take one tablet once daily if their blood pressure is already well controlled on bisoprolol fumarate and amlodipine besilate given as two separate single-ingredient products, at the same doses as those in the fixed-dose combination.
Side Effects
Common side effects of Bisoprolol Fumarate + Amlodipine Besilate include dizziness, headache, somnolence, palpitations and flushing. Some people feel coldness or numbness in the extremities. Stomach and bowel complaints can happen too, such as nausea, vomiting, diarrhea, constipation and abdominal pain. Edema (for example ankle edema) and fatigue are also common. Uncommon side effects are insomnia, mood changes (including anxiety), depression, sleep disorders, hypaesthesia, paresthesia, dysgeusia, tremor, visual disturbances (including diplopia) and tinnitus. Others in this group are AV conduction disturbances, worsening of pre-existing heart failure, bradycardia, hypotension, syncope and dyspnea. Bronchospasm can occur in patients with bronchial asthma or a history of obstructive airway disease. Rhinitis, dyspepsia, dry mouth, alopecia, purpura, skin discoloration, pruritus and exanthema are also listed. So are arthralgia, myalgia, muscular weakness, muscle cramps and back pain. Micturition disorder, nocturia, pollakisuria, potency disorders and gynecomastia may occur as well. The list ends with asthenia, chest pain, pain, malaise, weight increase and weight decrease. Rare side effects are allergic reactions mainly affecting the skin, nightmares, hallucinations, confusion, decreased tear secretion, hearing disorders and allergic rhinitis. Hepatitis, increased triglycerides and increased liver enzymes (ALAT, ASAT) are also rare.
Cautions & Contraindications
Warnings & Precautions
Patients with heart failure should be treated with caution, because a further worsening of the heart's pumping function can't be ruled out. Stopping bisoprolol suddenly may cause a temporary worsening of the patient's condition, especially in people with ischemic heart disease, so the treatment must not be stopped abruptly. Take care in patients whose liver function is impaired. Beta-blockers should be avoided in people with obstructive airways diseases, unless there are strong clinical reasons to use them. Because of the bisoprolol component, this medicine must be used with caution in the following: bronchospasm (bronchial asthma, chronic obstructive airways disease), where a bronchodilating treatment given alongside may be recommended, diabetes mellitus with large swings in blood glucose values, where the symptoms of hypoglycemia can be masked, strict fasting, ongoing desensitization therapy, first degree AV block, Prinzmetal's angina, and peripheral arterial occlusive disease. People with psoriasis, or a history of it, should be given beta-blockers (for example bisoprolol) only after the benefits and risks have been weighed carefully. The symptoms of thyrotoxicosis may be masked. If a patient is having general anesthesia, the anesthetist must know about the beta-blockade. If beta blocker therapy is thought necessary to withdraw before surgery, do it gradually and finish about 48 hours before anesthesia.
Contraindications
Bisoprolol Fumarate + Amlodipine Besilate must not be used in acute heart failure or during episodes of heart failure decompensation. It is also contraindicated in obstruction of the outflow tract of the left ventricle (for example, high grade aortic stenosis), cardiogenic shock, second or third degree AV block, sick sinus syndrome and sinoatrial block. Symptomatic bradycardia or hypotension, and severe bronchial asthma, are also on the list. The same applies to severe forms of peripheral arterial occlusive disease or severe forms of Raynaud's syndrome, untreated phaeochromocytoma and metabolic acidosis. Anyone with hypersensitivity to bisoprolol, amlodipine, dihydropyridine derivates or any of the excipients should not take it either.
Use in Special Populations
Geriatric use: Elderly people can take the usual doses, but be careful when the dose is increased.
Pediatric use: The safety and efficacy of Bisoprolol fumarate/amlodipine in children and adolescents below 18 years of age have not been established, and no data are available.
Patients with liver disease: When the liver is impaired, amlodipine may stay in the body for longer. Exact dosage recommendations for amlodipine have not been established, so the medicine should be given with special caution to these patients. In severe hepatic impairment, the daily dose of bisoprolol must not exceed 10 mg.
Patients with kidney disease: No dosage adjustment is needed for patients with mild to moderate renal impairment. Amlodipine is not dialyzable, and it should be given with particular caution to patients undergoing dialysis. In severe renal impairment (creatinine clearance <20 ml/min), the daily dose of bisoprolol must not exceed 10 mg.
Overdose
If a beta-blocker is taken in overdose, the signs most often expected are bradycardia, hypotension, bronchospasm, acute cardiac insufficiency and hypoglycemia. With a gross overdose of amlodipine, the available data suggest excessive peripheral vasodilation and possibly reflex tachycardia. Marked systemic hypotension, probably prolonged, has been reported, and it has gone as far as shock with a fatal outcome. In general, if an overdose occurs, treatment should be stopped, and supportive and symptomatic treatment is recommended.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store in a dry place below 30°C, away from light. Keep out of the reach of children.
Drug Interactions
Common questions about Bisocam 2.5 mg+5 mg
What is Bisocam 2.5 mg+5 mg Tablet?
Bisocam 2.5 mg+5 mg Tablet is a medicine that contains Bisoprolol Fumarate + Amlodipine Besilate. It is made by Square Pharmaceuticals PLC, Pabna. It belongs to the Anti-hypertensive group of medicines.
What is Bisocam used for?
Bisocam is used for: Hypertension.
What are the side effects of Bisocam?
Common side effects of Bisoprolol Fumarate + Amlodipine Besilate include dizziness, headache, somnolence, palpitations and flushing. Some people feel coldness or numbness in the extremities.
What happens if I take too much Bisocam?
If a beta-blocker is taken in overdose, the signs most often expected are bradycardia, hypotension, bronchospasm, acute cardiac insufficiency and hypoglycemia. With a gross overdose of amlodipine, the available data suggest excessive peripheral vasodilation and possibly reflex tachycardia. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Bisocam?
Store in a dry place below 30°C, away from light. Keep out of the reach of children.
Can I take other medicines with Bisocam?
Some medicines can interact with Bisoprolol Fumarate + Amlodipine Besilate, for example: Verapamil Hydrochloride, Diltiazem Hydrochloride, Cyclosporine, Mefloquine, Rifampicin, Tacrolimus. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Probis AM by Advanced Chemical Industries PLC. has the same ingredient and strength for ৳5.50 per unit, compared with ৳8.00 for Bisocam. Ask your doctor or pharmacist before switching.
Do I need a prescription for Bisocam?
Bisocam is a prescription (Rx) medicine. Take it as your doctor advises.