Indications
Bimatoprost + Timolol eye drops are used to lower the pressure inside the eye in adults who have open-angle glaucoma or ocular hypertension. They are meant for people whose pressure hasn't come down enough with a single medicine alone.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Bimatoprost is believed to lower intraocular pressure (IOP) in humans by increasing the outflow of aqueous humor through both the trabecular meshwork and the uveoscleral routes. It does this by mimicking a naturally occurring prostaglandin. Prostaglandins are a group of chemicals found in many places in the body, and in the eye they increase the drainage of aqueous humour out of the eyeball. Bimatoprost is a synthetic compound related to one of these natural prostaglandins, and it works by increasing that drainage. It may also lower the rate at which aqueous is formed in the eye. Both effects bring down the pressure inside the eye.
Timolol is a non-selective, beta-adrenergic receptor antagonist, similar to propranolol and nadolol. It does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity, but it does have a relatively high degree of lipid solubility. When timolol is applied to the eye, it reduces elevated intraocular pressure and also normal intraocular pressure, whether or not glaucoma is present. Elevated intraocular pressure is a major risk factor in the development of glaucomatous visual field loss and optic nerve damage.
Pregnancy & Breastfeeding
There isn't enough data on the use of the Bimatoprost / Timolol fixed combination in pregnant women. So it shouldn't be used during pregnancy unless it is clearly necessary.
Animal studies showed that Bimatoprost passes into rat's milk, and Timolol passes into human milk. For this reason, Bimatoprost / Timolol should not be used during breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.