Bempedoic Acid + Ezetimibe
Indications
Bempedoic Acid + Ezetimibe is used for adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who need their LDL-C lowered further. It is given alongside diet and the highest dose of statin therapy the patient can tolerate.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Bempedoic Acid is an adenosine triphosphate-citrate lyase (ACL) inhibitor. It lowers low-density lipoprotein cholesterol (LDL-C) by blocking cholesterol synthesis in the liver. ACL is an enzyme that works upstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase in the cholesterol biosynthesis pathway.
Bempedoic acid and its active metabolite, ESP15228, first need coenzyme A (CoA) activation by very long-chain acyl-CoA synthetase 1 (ACSVL1). This turns them into ETC-1002-CoA and ESP15228-CoA, respectively. ACSVL1 is found mainly in the liver. When ETC-1002-CoA inhibits ACL, cholesterol synthesis in the liver falls, and LDL-C in the blood goes down through upregulation of low-density lipoprotein receptors.
Ezetimibe is a potent and selective inhibitor of cholesterol absorption. It has been shown to reduce the overall delivery of cholesterol to the liver, and this promotes the synthesis of LDL receptors. The result is a reduction in serum LDL-C.
Pregnancy & Breastfeeding
Stop Bempedoic Acid & Ezetimibe once a pregnancy is recognised, unless the benefits of treatment outweigh the possible risk to the fetus. There are no data on its use in pregnant women, so we can't say whether it carries a risk of major birth defects, miscarriage, or harmful outcomes for the mother or the fetus.
Nothing is known about whether Bempedoic Acid & Ezetimibe passes into human or animal milk. The effects of the drug on a breastfed infant, and on milk production, are also unknown. Breastfeeding is not recommended during treatment.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.