Indications & Uses
Winolip E is indicated for:
Pharmacology
Bempedoic Acid is an adenosine triphosphate-citrate lyase (ACL) inhibitor. It lowers low-density lipoprotein cholesterol (LDL-C) by blocking cholesterol synthesis in the liver. ACL is an enzyme that works upstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase in the cholesterol biosynthesis pathway.
Bempedoic acid and its active metabolite, ESP15228, first need coenzyme A (CoA) activation by very long-chain acyl-CoA synthetase 1 (ACSVL1). This turns them into ETC-1002-CoA and ESP15228-CoA, respectively. ACSVL1 is found mainly in the liver. When ETC-1002-CoA inhibits ACL, cholesterol synthesis in the liver falls, and LDL-C in the blood goes down through upregulation of low-density lipoprotein receptors.
Ezetimibe is a potent and selective inhibitor of cholesterol absorption. It has been shown to reduce the overall delivery of cholesterol to the liver, and this promotes the synthesis of LDL receptors. The result is a reduction in serum LDL-C.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Take one tablet of Bempedoic Acid 180 mg & Ezetimibe 10 mg by mouth once a day. You can take it with or without food. The safety and effectiveness of this tablet haven't been established in children.
Side Effects
Side effects reported with Bempedoic Acid + Ezetimibe include upper respiratory tract infection, muscle spasms, hyperuricemia, back pain, abdominal pain or discomfort, bronchitis, pain in extremity, anemia and elevated liver enzymes.
Cautions & Contraindications
Warnings & Precautions
Serum uric acid can go up with Bempedoic acid & Ezetimibe. Uric acid levels should be checked from time to time, as the clinical situation calls for. Watch for signs and symptoms of hyperuricemia, and start treatment with urate-lowering drugs where appropriate. Tendon rupture has also been reported. Stop Bempedoic acid & Ezetimibe at the first sign of tendon rupture. The combination should be avoided in patients who have a history of tendon disorders or tendon rupture.
Contraindications
Don't give this to anyone who has a known hypersensitivity to ezetimibe tablets. Reactions to ezetimibe have been reported, and they include anaphylaxis, angioedema, rash and urticaria.
Pregnancy & Breastfeeding
Stop Bempedoic Acid & Ezetimibe once a pregnancy is recognised, unless the benefits of treatment outweigh the possible risk to the fetus. There are no data on its use in pregnant women, so we can't say whether it carries a risk of major birth defects, miscarriage, or harmful outcomes for the mother or the fetus.
Nothing is known about whether Bempedoic Acid & Ezetimibe passes into human or animal milk. The effects of the drug on a breastfed infant, and on milk production, are also unknown. Breastfeeding is not recommended during treatment.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Bempedoic Acid + Ezetimibe at a temperature not above 30°C. Keep it away from light, and keep it out of the reach of children.
Drug Interactions
Common questions about Winolip E 180 mg
What is Winolip E 180 mg Tablet?
Winolip E 180 mg Tablet is a medicine that contains Bempedoic Acid + Ezetimibe. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Other Anti-anginal & Anti-ischaemic drugs group of medicines.
What is Winolip E used for?
Winolip E is used for: Hyperlipidemia.
What are the side effects of Winolip E?
Side effects reported with Bempedoic Acid + Ezetimibe include upper respiratory tract infection, muscle spasms, hyperuricemia, back pain, abdominal pain or discomfort, bronchitis, pain in extremity, anemia and elevated liver enzymes.
Can I take Winolip E during pregnancy or while breastfeeding?
Stop Bempedoic Acid & Ezetimibe once a pregnancy is recognised, unless the benefits of treatment outweigh the possible risk to the fetus. There are no data on its use in pregnant women, so we can't say whether it carries a risk of major birth defects, miscarriage, or harmful outcomes for the mother or the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Winolip E?
Store Bempedoic Acid + Ezetimibe at a temperature not above 30°C. Keep it away from light, and keep it out of the reach of children.
Can I take other medicines with Winolip E?
Some medicines can interact with Bempedoic Acid + Ezetimibe, for example: Ezetimibe, Simvastatin, Bempedoic Acid, Pravastatin Sodium. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Winolip E?
Winolip E is a prescription (Rx) medicine. Take it as your doctor advises.