Informational only — Not medical advice. Always consult a licensed healthcare provider.

Shasthya স্বাস্থ্য · Health, made simple
বাং
Community data Updated 23 hours ago
🌐 বাংলায় দেখুন

Indications

Erectile Dysfunction

Avanafil is a phosphodiesterase 5 (PDE5) inhibitor, and doctors prescribe it to treat erectile dysfunction.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Avanafil is a selective phosphodiesterase 5 (PDE5) enzyme inhibitor. Doctors use it to treat erectile dysfunction caused by diabetes, age induced oxidative stress or other complications. It works by blocking the cGMP specific phosphodiesterase 5 (PDE5), the enzyme that breaks down cGMP in the corpus cavernosum around the penis.

An erection during sexual stimulation happens when more blood flows into the penis. This follows the relaxation of the penile arteries and the smooth muscle of the corpus cavernosum. Nitric oxide (NO) is released from nerve terminals and endothelial cells, and this stimulates smooth muscle cells to make cGMP. Cyclic GMP then relaxes the smooth muscle and lets more blood flow into the corpus cavernosum. Because avanafil inhibits PDE5, the amount of cGMP rises and erectile function improves.

Pregnancy & Breastfeeding

Avanafil is listed under Pregnancy Category C. It is not meant for use in women.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: The usual starting dose of Avanafil is 100 mg, taken about 15 minutes before sexual activity and only when needed. You can take it with or without food. Don't take it more than once a day. Depending on how well it works and how well you tolerate it, the doctor may raise the dose to 200 mg or lower it to 50 mg. The aim is to use the lowest dose that gives benefit. Nitrates in any form must not be used together with Avanafil, as this is contraindicated. Strong CYP3A4 inhibitors should not be used with it either. If a patient is taking a moderate CYP3A4 inhibitor, the dose should be no more than 50 mg in a 24-hour period. For patients on stable alpha-blocker therapy, the recommended starting dose of Avanafil is 50 mg.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.