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Other brands with the same active ingredient
These brands contain the same active ingredient (Avanafil). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
NIHAR 50 is indicated for:
Pharmacology
Avanafil is a selective phosphodiesterase 5 (PDE5) enzyme inhibitor. Doctors use it to treat erectile dysfunction caused by diabetes, age induced oxidative stress or other complications. It works by blocking the cGMP specific phosphodiesterase 5 (PDE5), the enzyme that breaks down cGMP in the corpus cavernosum around the penis.
An erection during sexual stimulation happens when more blood flows into the penis. This follows the relaxation of the penile arteries and the smooth muscle of the corpus cavernosum. Nitric oxide (NO) is released from nerve terminals and endothelial cells, and this stimulates smooth muscle cells to make cGMP. Cyclic GMP then relaxes the smooth muscle and lets more blood flow into the corpus cavernosum. Because avanafil inhibits PDE5, the amount of cGMP rises and erectile function improves.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual starting dose of Avanafil is 100 mg, taken about 15 minutes before sexual activity and only when needed. You can take it with or without food. Don't take it more than once a day. Depending on how well it works and how well you tolerate it, the doctor may raise the dose to 200 mg or lower it to 50 mg. The aim is to use the lowest dose that gives benefit.
Nitrates in any form must not be used together with Avanafil, as this is contraindicated. Strong CYP3A4 inhibitors should not be used with it either. If a patient is taking a moderate CYP3A4 inhibitor, the dose should be no more than 50 mg in a 24-hour period. For patients on stable alpha-blocker therapy, the recommended starting dose of Avanafil is 50 mg.
Side Effects
The most common side effects of Avanafil, seen in 2% or more of people, are headache, flushing, nasal congestion, nasopharyngitis and back pain.
Cautions & Contraindications
Warnings & Precautions
Patients should not use Avanafil if sexual activity is inadvisable because of their heart condition or for any other reason. Taking Avanafil with alpha-blockers, other antihypertensives, or a large amount of alcohol (more than 3 units) may lead to hypotension. If an erection lasts longer than 4 hours, the patient should get emergency treatment. Patients should stop taking Avanafil and seek medical care if they suddenly lose vision in one or both eyes, as this could be a sign of Non-Arteritic Ischemic Optic Neuropathy (NAION). Talk with patients about the higher risk of NAION in those who have had NAION before. Patients should also stop taking Avanafil and get prompt medical attention if their hearing suddenly decreases or is lost.
Contraindications
Avanafil must not be given to anyone who is using any form of organic nitrate. It is also contraindicated in patients who are known to be hypersensitive to Avanafil. And it must not be taken together with guanylate cyclase (GC) stimulators such as riociguat and vericiguat.
Pregnancy & Breastfeeding
Avanafil is listed under Pregnancy Category C. It is not meant for use in women.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric use
Avanafil is not indicated for use in pediatric patients.
Geriatric use
About 23% of the people in the clinical studies of Avanafil were 65 and over. The studies found no overall difference in efficacy or safety between those over 65 years of age and younger subjects, so no dose adjustment is warranted based on age alone. Still, some older people may be more sensitive to the medicine, and this should be considered.
Renal and hepatic impairment
Do not use Avanafil in patients with severe renal and hepatic impairment.
Overdose
Avanafil has been given to healthy subjects in single doses of up to 800 mg, and to patients in multiple doses of up to 300 mg. If an overdose happens, use standard supportive measures as needed. Renal dialysis isn't expected to speed up clearance of Avanafil, because the medicine is highly bound to plasma proteins and is not significantly eliminated in the urine.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Avanafil below 25°C. Store it away from light and from damp places, and keep it out of reach of children.
Drug Interactions
Common questions about NIHAR 50 50 mg
What is NIHAR 50 50 mg Tablet?
NIHAR 50 50 mg Tablet is a medicine that contains Avanafil. It is made by Eskayef Pharmaceuticals Ltd., Tongi,Gazipur. It belongs to the Drugs for Erectile Dysfunction group of medicines.
What is NIHAR 50 used for?
NIHAR 50 is used for: Erectile Dysfunction.
What are the side effects of NIHAR 50?
The most common side effects of Avanafil, seen in 2% or more of people, are headache, flushing, nasal congestion, nasopharyngitis and back pain.
Can I take NIHAR 50 during pregnancy or while breastfeeding?
Avanafil is listed under Pregnancy Category C. It is not meant for use in women. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much NIHAR 50?
Avanafil has been given to healthy subjects in single doses of up to 800 mg, and to patients in multiple doses of up to 300 mg. If an overdose happens, use standard supportive measures as needed. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store NIHAR 50?
Keep Avanafil below 25°C. Store it away from light and from damp places, and keep it out of reach of children.
Can I take other medicines with NIHAR 50?
Some medicines can interact with Avanafil, for example: Isosorbide Dinitrate + Hydralazine Hydrochloride, Erythromycin, Ritonavir, Ketoconazole. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for NIHAR 50?
NIHAR 50 is a prescription (Rx) medicine. Take it as your doctor advises.