Indications
Aspirin + Dipyridamole is an antiplatelet medicine that combines two drugs. It is used to lower the risk of stroke in people who have had a transient ischemic attack (a temporary loss of blood supply to the brain) or a complete ischemic stroke caused by thrombosis.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Aspirin + Dipyridamole is a combination of two anti-platelet medicines, Aspirin and Dipyridamole, taken by mouth. Aspirin blocks platelet cyclooxygenase, and this block cannot be reversed. As a result, the body makes less thromboxane A2, and the platelets stick together less.
Dipyridamole also stops platelets from clumping, but it works in a different way. It blocks the uptake of adenosine into platelets, and adenosine is a strong mediator of vasodilation. So the local concentration of adenosine goes up. This raises the level of cAMP (cyclic-adenosine monophosphate), which lowers the ca++ concentration and so prevents platelet aggregation.
Dipyridamole also inhibits phosphodiesterase (PDE), especially cyclic-guanosine monophosphate-PDE (cGMP-PDE). This increases the cGMP produced by EDRF (endothelium-derived relaxing factor) Nitric oxide, which is a potent vasodilator.
Pregnancy & Breastfeeding
Aspirin + Dipyridamole is Pregnancy Category D. The aspirin in it can cause heavy blood loss at delivery, and it can also lengthen the pregnancy and prolong labor. For this reason, the capsule should be avoided in the third trimester and during labor and delivery.
Both dipyridamole and aspirin pass into human milk. So this capsule should not be given to a woman who is breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.