Pricing
Prices are indicative MRP and may vary by pharmacy. Trend compares against the last recorded price.
All price changes →More from Aggreno
Other strengths and forms by Ziska Pharmaceuticals Ltd.
Indications & Uses
Aspirin + Dipyridamole is an antiplatelet medicine that combines two drugs. It is used to lower the risk of stroke in people who have had a transient ischemic attack (a temporary loss of blood supply to the brain) or a complete ischemic stroke caused by thrombosis.
Pharmacology
Aspirin + Dipyridamole is a combination of two anti-platelet medicines, Aspirin and Dipyridamole, taken by mouth. Aspirin blocks platelet cyclooxygenase, and this block cannot be reversed. As a result, the body makes less thromboxane A2, and the platelets stick together less.
Dipyridamole also stops platelets from clumping, but it works in a different way. It blocks the uptake of adenosine into platelets, and adenosine is a strong mediator of vasodilation. So the local concentration of adenosine goes up. This raises the level of cAMP (cyclic-adenosine monophosphate), which lowers the ca++ concentration and so prevents platelet aggregation.
Dipyridamole also inhibits phosphodiesterase (PDE), especially cyclic-guanosine monophosphate-PDE (cGMP-PDE). This increases the cGMP produced by EDRF (endothelium-derived relaxing factor) Nitric oxide, which is a potent vasodilator.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual dose of Aspirin + Dipyridamole is one capsule by mouth twice a day, one in the morning and one in the evening. Swallow the capsule whole and don't chew it. You can take it with or without food.
Pediatric Use: The safety and effectiveness of this capsule in children have not been studied, so it is not recommended for the pediatric population.
Side Effects
People who take aspirin with dipyridamole most often report headache, dyspepsia, abdominal pain, nausea and diarrhea.
Cautions & Contraindications
Warnings & Precautions
Aspirin and Dipyridamole can't be swapped with the separate Aspirin and Dipyridamole tablets, so don't treat them as the same thing. This medicine raises the risk of Intracranial Hemorrhage and Gastrointestinal Bleeding. Avoid it in patients with peptic ulcer, coronary artery diseases, hypotension, and severe renal failure or hepatic insufficiency.
Contraindications
Hypersensitivity Don't give this capsule to patients who are known to be hypersensitive to any of its components. Allergy Aspirin must not be used in patients with a known allergy to nonsteroidal anti-inflammatory drugs, or in patients with the syndrome of asthma, rhinitis and nasal polyps. Aspirin may cause severe urticaria, angioedema or bronchospasm. Reye Syndrome Aspirin should not be used in children or teenagers with viral infections, because of the risk of Reye syndrome.
Pregnancy & Breastfeeding
Aspirin + Dipyridamole is Pregnancy Category D. The aspirin in it can cause heavy blood loss at delivery, and it can also lengthen the pregnancy and prolong labor. For this reason, the capsule should be avoided in the third trimester and during labor and delivery.
Both dipyridamole and aspirin pass into human milk. So this capsule should not be given to a woman who is breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
An overdose of Aspirin + Dipyridamole is likely to show the signs and symptoms of both Dipyridamole overdose and Aspirin overdose. With Dipyridamole, the effects are mainly on circulation. The person may feel warm, with flushes, sweating, restlessness, weakness and dizziness, and a drop in blood pressure and a fast heartbeat (tachycardia) might also be seen. Aspirin overdose shows up as tinnitus, hyperthermia and hypovolemia.
Treatment is mainly supportive of the vital functions. It also includes increasing drug elimination, correcting acid-base disturbances, and gastric emptying or lavage as soon as possible after the medicine has been taken. Fluid and electrolyte balance must be maintained, and to control the hypoglycemic condition, intravenous fluid and an infusion of glucose must be given. Xanthine derivatives (for example aminophylline) may reverse the circulatory effects of Dipyridamole overdose.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Aspirin + Dipyridamole in a cool, dry place and away from light. Make sure children can't reach it.
Common questions about Aggreno 25 mg+200 mg
What is Aggreno 25 mg+200 mg Capsule (Extended Release)?
Aggreno 25 mg+200 mg Capsule (Extended Release) is a medicine that contains Aspirin + Dipyridamole. It is made by Ziska Pharmaceuticals Ltd. It belongs to the Anti-platelet drugs group of medicines.
What is Aggreno used for?
Aspirin + Dipyridamole is an antiplatelet medicine that combines two drugs. It is used to lower the risk of stroke in people who have had a transient ischemic attack (a temporary loss of blood supply to the brain) or a complete ischemic stroke caused by thrombosis.
What are the side effects of Aggreno?
People who take aspirin with dipyridamole most often report headache, dyspepsia, abdominal pain, nausea and diarrhea.
Can I take Aggreno during pregnancy or while breastfeeding?
Aspirin + Dipyridamole is Pregnancy Category D. The aspirin in it can cause heavy blood loss at delivery, and it can also lengthen the pregnancy and prolong labor. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Aggreno?
An overdose of Aspirin + Dipyridamole is likely to show the signs and symptoms of both Dipyridamole overdose and Aspirin overdose. With Dipyridamole, the effects are mainly on circulation. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Aggreno?
Keep Aspirin + Dipyridamole in a cool, dry place and away from light. Make sure children can't reach it.
Is there a cheaper medicine with the same ingredient?
Aggreno is already among the lowest-priced brands of Aspirin + Dipyridamole at this strength.
Do I need a prescription for Aggreno?
Aggreno is a prescription (Rx) medicine. Take it as your doctor advises.