Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 23 hours ago

Indications

Asenapine Maleate is used for schizophrenia in adults and for bipolar I disorder. In bipolar I disorder, it is given as acute monotherapy for manic or mixed episodes in adults and in paediatric patients 10 to 17 years of age. It is also used as adjunctive treatment to lithium or valproate in adults, and as maintenance monotherapy in adults.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Nobody knows exactly how asenapine works in schizophrenia and bipolar I disorder. One suggestion is that its effect in schizophrenia may come from a combination of antagonist activity at D2 and 5-HT 2A receptors.

Pregnancy & Breastfeeding

Babies born to mothers who took Asenapine Maleate in the third trimester may have extrapyramidal symptoms, withdrawal symptoms, or both. No lactation studies have been done, so we don't know whether asenapine passes into human milk. We also don't know what effect it has on a breastfed baby, or whether it changes milk production.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: For schizophrenia in adults, the initial dose of Asenapine Maleate is 5 mg sublingually, twice daily. The recommended dose is the same, 5 mg sublingually, twice daily, and the maximum is 10 mg sublingually, twice daily. For maintenance treatment of schizophrenia in adults, the initial dose is again 5 mg sublingually, twice daily. The recommended dose is 5 to 10 mg sublingually, twice daily, and the maximum is 10 mg sublingually, twice daily. For bipolar mania in adults, as acute and maintenance monotherapy, the initial dose is 5 to 10 mg sublingually, twice daily. The recommended dose is 5 to 10 mg sublingually, twice daily, and the maximum is 10 mg sublingually, twice daily. For bipolar mania in pediatric patients aged 10 to 17 years, as monotherapy, the initial dose is 2.5 mg sublingually, twice daily. The recommended dose is 2.5 to 10 mg sublingually, twice daily, and the maximum is 10 mg sublingually, twice daily. For bipolar mania in adults when asenapine is used as an adjunct to lithium or valproate, the initial dose is 5 mg sublingually, twice daily. The recommended dose is 5 to 10 mg sublingually, twice daily, and the maximum is 10 mg sublingually, twice daily. Don't swallow the sublingual tablets. Place the tablet under the tongue and leave it to dissolve completely. It dissolves in saliva within seconds. Avoid eating and drinking for 10 minutes after taking it.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.