Pricing
Prices are indicative MRP and may vary by pharmacy. Trend compares against the last recorded price.
All price changes →Indications & Uses
Zukaria is indicated for:
Pharmacology
Nobody knows exactly how asenapine works in schizophrenia and bipolar I disorder. One suggestion is that its effect in schizophrenia may come from a combination of antagonist activity at D2 and 5-HT 2A receptors.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For schizophrenia in adults, the initial dose of Asenapine Maleate is 5 mg sublingually, twice daily. The recommended dose is the same, 5 mg sublingually, twice daily, and the maximum is 10 mg sublingually, twice daily.
For maintenance treatment of schizophrenia in adults, the initial dose is again 5 mg sublingually, twice daily. The recommended dose is 5 to 10 mg sublingually, twice daily, and the maximum is 10 mg sublingually, twice daily.
For bipolar mania in adults, as acute and maintenance monotherapy, the initial dose is 5 to 10 mg sublingually, twice daily. The recommended dose is 5 to 10 mg sublingually, twice daily, and the maximum is 10 mg sublingually, twice daily.
For bipolar mania in pediatric patients aged 10 to 17 years, as monotherapy, the initial dose is 2.5 mg sublingually, twice daily. The recommended dose is 2.5 to 10 mg sublingually, twice daily, and the maximum is 10 mg sublingually, twice daily.
For bipolar mania in adults when asenapine is used as an adjunct to lithium or valproate, the initial dose is 5 mg sublingually, twice daily. The recommended dose is 5 to 10 mg sublingually, twice daily, and the maximum is 10 mg sublingually, twice daily.
Don't swallow the sublingual tablets. Place the tablet under the tongue and leave it to dissolve completely. It dissolves in saliva within seconds. Avoid eating and drinking for 10 minutes after taking it.
Side Effects
The most common side effects of asenapine are akathisia, somnolence, oral hypoesthesia, dizziness, extrapyramidal symptoms, nausea, increased appetite, fatigue and increased weight.
Cautions & Contraindications
Warnings & Precautions
Doctors should take care when prescribing asenapine to elderly patients with dementia-related psychosis. The same care applies to people with QT prolongation, neuroleptic malignant syndrome, tardive dyskinesia, metabolic changes, orthostatic hypotension, leukopenia, neutropenia, agranulocytosis or seizures. Asenapine can also cause cognitive and motor impairment, so this needs to be kept in mind too.
Contraindications
Asenapine must not be given to people with severe hepatic impairment (Child-Pugh C). It must also not be given to anyone who has had a hypersensitivity reaction to asenapine before. These reactions have included anaphylaxis, angioedema, hypotension, tachycardia, swollen tongue, dyspnea, wheezing and rash.
Pregnancy & Breastfeeding
Babies born to mothers who took Asenapine Maleate in the third trimester may have extrapyramidal symptoms, withdrawal symptoms, or both. No lactation studies have been done, so we don't know whether asenapine passes into human milk. We also don't know what effect it has on a breastfed baby, or whether it changes milk production.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
There is no specific antidote for asenapine. In an overdose, treatment is supportive: keep the airway clear, make sure the patient is getting enough oxygen and ventilation, and manage the symptoms as they appear. If severe extrapyramidal symptoms develop, give anticholinergic medicine. The patient should stay under close medical supervision and monitoring until they recover.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Asenapine Maleate at or below 30°C. Keep it away from light, and keep it out of the reach of children.
Drug Interactions
Common questions about Zukaria 5 mg
What is Zukaria 5 mg Sublingual Tablet?
Zukaria 5 mg Sublingual Tablet is a medicine that contains Asenapine Maleate. It is made by Incepta Pharmaceuticals Ltd.
What is Zukaria used for?
Zukaria is used for: Schizophrenia.
What are the side effects of Zukaria?
The most common side effects of asenapine are akathisia, somnolence, oral hypoesthesia, dizziness, extrapyramidal symptoms, nausea, increased appetite, fatigue and increased weight.
Can I take Zukaria during pregnancy or while breastfeeding?
Babies born to mothers who took Asenapine Maleate in the third trimester may have extrapyramidal symptoms, withdrawal symptoms, or both. No lactation studies have been done, so we don't know whether asenapine passes into human milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Zukaria?
There is no specific antidote for asenapine. In an overdose, treatment is supportive: keep the airway clear, make sure the patient is getting enough oxygen and ventilation, and manage the symptoms as they appear. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Zukaria?
Store Asenapine Maleate at or below 30°C. Keep it away from light, and keep it out of the reach of children.
Can I take other medicines with Zukaria?
Some medicines can interact with Asenapine Maleate, for example: Paroxetine, Ravuconazole. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Zukaria is already among the lowest-priced brands of Asenapine Maleate at this strength.
Do I need a prescription for Zukaria?
Zukaria is a prescription (Rx) medicine. Take it as your doctor advises.