Articaine Hydrochloride + Epinephrine Bitartrate

Indications

Articaine Hydrochloride + Epinephrine Bitartrate is used for local, infiltrative or conductive anesthesia in dental and periodontal procedures, whether they are simple or complex.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Articaine hydrochloride with Epinephrine bitartrate comes as a sterile dental cartridge, with both ingredients in an aqueous solution. Articaine is a local anaesthetic of the amide type. The Epinephrine added to it is an adrenergic vasoconstrictor. It reduces bleeding during surgery and slows the passage of Articaine into the general circulation, so the active concentration in the tissue is maintained for longer.

After Articaine hydrochloride 4% with Epinephrine 1:100,000 is given, anaesthesia sets in at about 3.5 minutes (range 1 to 6 minutes). The mean duration of anaesthesia is about 68 minutes, with a range of 20 to 175 minutes. Peak plasma concentration is reached 25 minutes after a single injected dose.

Approximately 60-80% of Articaine hydrochloride is bound to human serum albumin and γ globulins. Its elimination half-life is about 1.8 hours. Articaine is excreted mainly in the urine, which accounts for 53-57% of the administered dose.

Pregnancy & Breastfeeding

There are no adequate and well controlled studies of Articaine Hydrochloride with Epinephrine Bitartrate in pregnant women. So doctors should use this product during pregnancy only if the likely benefit justifies the possible risk to the fetus. It isn't known whether Articaine passes into human milk, so take care when giving this product to a nursing mother.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: The recommended dose of Articaine Hydrochloride + Epinephrine Bitartrate for normal healthy adults, given by submucosal infiltration and/or nerve block, is as follows. Infiltration takes 0.5 mL to 2.5 mL, or 20 mg to 100 mg of articaine. Nerve block takes 0.5 mL to 3.4 mL, or 20 mg to 136 mg of articaine. Oral surgery takes 1.0 mL to 5.1 mL, or 40 mg to 204 mg of articaine. These volumes are only a guide, and other volumes may be used as long as the total maximum recommended dose is not exceeded. In a normal healthy adult, the maximum recommended dose of articaine hydrochloride given by submucosal infiltration and/or nerve block should not exceed 7 mg/kg. Children older than 4 years should also not receive more than 7 mg/kg (0.175 mL/kg) body weight of articaine hydrochloride. The dose for a child should be decided by the child's age and weight and by the magnitude of the operation.