Pricing
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Articaine Hydrochloride + Epinephrine Bitartrate is used for local, infiltrative or conductive anesthesia in dental and periodontal procedures, whether they are simple or complex.
Pharmacology
Articaine hydrochloride with Epinephrine bitartrate comes as a sterile dental cartridge, with both ingredients in an aqueous solution. Articaine is a local anaesthetic of the amide type. The Epinephrine added to it is an adrenergic vasoconstrictor. It reduces bleeding during surgery and slows the passage of Articaine into the general circulation, so the active concentration in the tissue is maintained for longer.
After Articaine hydrochloride 4% with Epinephrine 1:100,000 is given, anaesthesia sets in at about 3.5 minutes (range 1 to 6 minutes). The mean duration of anaesthesia is about 68 minutes, with a range of 20 to 175 minutes. Peak plasma concentration is reached 25 minutes after a single injected dose.
Approximately 60-80% of Articaine hydrochloride is bound to human serum albumin and γ globulins. Its elimination half-life is about 1.8 hours. Articaine is excreted mainly in the urine, which accounts for 53-57% of the administered dose.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The recommended dose of Articaine Hydrochloride + Epinephrine Bitartrate for normal healthy adults, given by submucosal infiltration and/or nerve block, is as follows. Infiltration takes 0.5 mL to 2.5 mL, or 20 mg to 100 mg of articaine. Nerve block takes 0.5 mL to 3.4 mL, or 20 mg to 136 mg of articaine. Oral surgery takes 1.0 mL to 5.1 mL, or 40 mg to 204 mg of articaine. These volumes are only a guide, and other volumes may be used as long as the total maximum recommended dose is not exceeded. In a normal healthy adult, the maximum recommended dose of articaine hydrochloride given by submucosal infiltration and/or nerve block should not exceed 7 mg/kg. Children older than 4 years should also not receive more than 7 mg/kg (0.175 mL/kg) body weight of articaine hydrochloride. The dose for a child should be decided by the child's age and weight and by the magnitude of the operation.
Side Effects
Some patients taking Articaine Hydrochloride with Epinephrine Bitartrate have reported these side effects: abdominal pain, accidental injury, asthenia, back pain, injection site pain, malaise, neck pain, haemorrhage, migraine, tachycardia, constipation, diarrhoea, dyspepsia, glossitis, tongue oedema, tooth disorder, vomiting, dizziness, dry mouth, increased salivation, nervousness, neuropathy, pharyngitis, rhinitis, pruritus, skin disorder and dysmenorrhoea.
Cautions & Contraindications
Warnings & Precautions
If Articaine Hydrochloride + Epinephrine Bitartrate is injected into a blood vessel by accident, it may cause convulsions. These can be followed by central nervous system or cardiorespiratory depression and coma, and may end in respiratory arrest. Dental practitioners and clinicians who use local anaesthetic agents should know how to diagnose and manage the emergencies that can arise from their use. Resuscitative equipment, oxygen and other resuscitative drugs should be ready for immediate use. Use the lowest dose that gives effective anaesthesia, so that high plasma levels and serious adverse effects are avoided. Repeated doses of Articaine HCl and Epinephrine may raise blood levels significantly with each dose, because the drug or its metabolites can accumulate. How well a patient tolerates high blood levels varies with their condition. Debilitated, elderly, acutely ill and paediatric patients should be given reduced doses that suit their age and physical condition. The medicine should also be used with caution in patients with heart block. A local anaesthetic solution that contains a vasoconstrictor, like this dental cartridge, should be used cautiously. Patients with peripheral vascular disease and those with hypertensive vascular disease may show an exaggerated vasoconstrictor response, and ischaemic injury or necrosis may result. Use it with caution in patients during or after the administration of potent general anaesthetic agents, since cardiac arrhythmias may occur under those conditions. Systemic absorption of local anaesthetics can affect the central nervous and cardiovascular systems. At the blood concentrations reached with therapeutic doses, changes in cardiac conduction, excitability, refractoriness, contractility and peripheral vascular resistance are minimal.
Contraindications
Articaine Hydrochloride with Epinephrine Bitartrate must not be given to anyone with a known history of hypersensitivity to amide-type local anesthetics. It is also contraindicated in patients known to be hypersensitive to sodium metabisulphite.
Pregnancy & Breastfeeding
There are no adequate and well controlled studies of Articaine Hydrochloride with Epinephrine Bitartrate in pregnant women. So doctors should use this product during pregnancy only if the likely benefit justifies the possible risk to the fetus. It isn't known whether Articaine passes into human milk, so take care when giving this product to a nursing mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Common questions about Arocaine-A DC 4%+0.001%
What is Arocaine-A DC 4%+0.001% Injection?
Arocaine-A DC 4%+0.001% Injection is a medicine that contains Articaine Hydrochloride + Epinephrine Bitartrate. It is made by Jayson Pharmaceuticals Ltd. It belongs to the Local & Surface anesthesia group of medicines.
What is Arocaine-A DC used for?
Articaine Hydrochloride + Epinephrine Bitartrate is used for local, infiltrative or conductive anesthesia in dental and periodontal procedures, whether they are simple or complex.
What are the side effects of Arocaine-A DC?
Some patients taking Articaine Hydrochloride with Epinephrine Bitartrate have reported these side effects: abdominal pain, accidental injury, asthenia, back pain, injection site pain, malaise, neck pain, haemorrhage, migraine, tachycardia, constipation, diarrhoea, dyspepsia, glossitis, tongue oedema, tooth disorder, vomiting, dizziness, dry mouth, increased salivation, nervousness, neuropathy, pharyngitis, rhinitis, pruritus, skin disorder and dysmenorrhoea.
Can I take Arocaine-A DC during pregnancy or while breastfeeding?
There are no adequate and well controlled studies of Articaine Hydrochloride with Epinephrine Bitartrate in pregnant women. So doctors should use this product during pregnancy only if the likely benefit justifies the possible risk to the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Do I need a prescription for Arocaine-A DC?
Arocaine-A DC is a prescription (Rx) medicine. Take it as your doctor advises.