Anidulafungin

Adults: Duration of treatment: there isn't enough data to support the 100 mg dose for longer than 35 days of treatment. Patients with renal and hepatic impairment: no dose adjustment is needed for mild, moderate or severe hepatic impairment. No dose adjustment is needed for any degree of renal insufficiency either, including patients on dialysis. Other special populations: adult patients need no dose adjustment based on gender, weight, ethnicity, HIV positivity or old age. Candidemia and other forms of Candida infections Adults get a 200 mg loading dose on Day 1, then 100 mg once daily as the maintenance dose for at least 14 days after the last positive culture. Pediatric patients (1 month of age and older) get a 3 mg/kg loading dose on Day 1 (not to exceed 200 mg), then 1.5 mg/kg once daily (not to exceed 100 mg) as the maintenance dose, also for at least 14 days after the last positive culture. Esophageal Candidiasis Adults get a 100 mg loading dose on Day 1, then 50 mg once daily as the maintenance dose for a minimum of 14 days and for at least 7 days after symptoms resolve. This use is not approved in pediatric patients. Method of administration: Anidulafungin is for intravenous use only. Reconstitute it with water for injection to a concentration of 3.33 mg/mL, then dilute it further to a concentration of 0.77 mg/mL. The recommended rate of infusion should not exceed 1.1 mg/min (equivalent to 1.4 mL/min when reconstituted and diluted as instructed). Anidulafungin must not be given as a bolus injection.