Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Amlodipine Besilate + Valsartan

Combined antihypertensive preparations Prescription
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Indications

Amlodipine Besilate + Valsartan is used to treat hypertension. Because it is a fixed combination, it is not meant for starting treatment in someone who has not been treated for hypertension before.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Amlodipine is a dihydropyridine calcium channel blocker. It stops calcium ions from moving into vascular smooth muscle and cardiac muscle. Valsartan works differently. It blocks the vasoconstrictor and aldosterone-secreting effects of Angiotensin II by selectively stopping Angiotensin II from binding to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Because of this, its action does not depend on the pathways that make Angiotensin II.

Amlodipine and Valsartan have both been shown to lower blood pressure effectively. Each one does this by reducing peripheral resistance, but blocking calcium influx and reducing Angiotensin II vasoconstriction are complementary mechanisms.

Pregnancy & Breastfeeding

Amlodipine Besilate + Valsartan is Pregnancy Category D. Nobody knows yet whether amlodipine or valsartan passes into human breast milk. Since the nursing infant could be harmed, the choice has to be made between stopping breastfeeding and stopping the medicine, and that choice should depend on how much the mother needs the medicine.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Treatment of hypertension: Amlodipine works well for high blood pressure at once daily doses of 2.5 mg to 10 mg, and Valsartan works well at doses of 80 mg to 320 mg. In clinical trials of Amlodipine and Valsartan together, using amlodipine 5 mg to 10 mg with Valsartan 160 mg to 320 mg, the blood pressure lowering effect grew as the dose went up. Most of the effect is reached within 2 weeks of starting treatment or changing the dose. If needed, the dose can be raised after 1 to 2 weeks of treatment, up to a maximum of 10/320 mg once daily, to control blood pressure. Amlodipine Besilate + Valsartan can be taken with or without food, and it can be given together with other antihypertensive medicines. A patient whose blood pressure isn't properly controlled on Amlodipine alone or on Valsartan alone may be switched to this combination. Elderly patients: Amlodipine is cleared more slowly in older people, so treatment should usually start at 2.5 mg. Renal impairment: No change to the starting dose is needed in mild or moderate renal impairment. In severe renal impairment, increase the dose slowly. Hepatic impairment: No change to the starting dose is needed in mild or moderate liver insufficiency. In hepatic impairment, increase the dose slowly.