Amlodipine Besilate + Olmesartan Medoxomil

Amlodipine is a dihydropyridine calcium channel blocker. It stops calcium ions from moving across the cell membrane into vascular smooth muscle and cardiac muscle, and its effect is greater on vascular smooth muscle cells than on cardiac muscle cells. Amlodipine is a peripheral arterial vasodilator. It acts directly on vascular smooth muscle, which lowers peripheral vascular resistance and so reduces blood pressure.

Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE). It is a potent vasoconstrictor, the primary vasoactive hormone of the Renin-angiotensin system, and an important part of the pathophysiology of hypertension. It also stimulates aldosterone secretion by the adrenal cortex. Olmesartan Medoxomil blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II. It does this by selectively blocking the binding of angiotensin II to the AT1 receptor, which is found in many tissues (e.g. vascular smooth muscle, adrenal gland). In vitro binding studies show that Olmesartan Medoxomil is a reversible, competitive inhibitor of the AT1 receptor. It does not inhibit ACE (kinase II, the enzyme that converts angiotensin I to angiotensin II and breaks down bradykinin).