Pricing
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Indications & Uses
Calnor is indicated for:
Pharmacology
Amlodipine is a dihydropyridine calcium channel blocker. It stops calcium ions from moving across the cell membrane into vascular smooth muscle and cardiac muscle, and its effect is greater on vascular smooth muscle cells than on cardiac muscle cells. Amlodipine is a peripheral arterial vasodilator. It acts directly on vascular smooth muscle, which lowers peripheral vascular resistance and so reduces blood pressure.
Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE). It is a potent vasoconstrictor, the primary vasoactive hormone of the Renin-angiotensin system, and an important part of the pathophysiology of hypertension. It also stimulates aldosterone secretion by the adrenal cortex. Olmesartan Medoxomil blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II. It does this by selectively blocking the binding of angiotensin II to the AT1 receptor, which is found in many tissues (e.g. vascular smooth muscle, adrenal gland). In vitro binding studies show that Olmesartan Medoxomil is a reversible, competitive inhibitor of the AT1 receptor. It does not inhibit ACE (kinase II, the enzyme that converts angiotensin I to angiotensin II and breaks down bradykinin).
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Patients taking amlodipine and olmesartan medoxomil as separate, individually titrated medicines can be switched to the Amlodipine Besilate + Olmesartan Medoxomil combination instead. The combination can also be given with higher amounts of amlodipine, olmesartan medoxomil, or both, as needed.
For initial therapy, start with 5/20 mg once daily for 1 to 2 weeks, then adjust as needed up to a maximum of 10/40 mg once daily. Amlodipine is cleared more slowly in elderly patients, so the recommended starting dose of amlodipine is 2.5 mg in patients 75 years. The lowest dose of the combination is 5/20 mg, so it isn't recommended as initial therapy in patients older than 75 years.
Side Effects
The most common side effects of Amlodipine Besilate + Olmesartan Medoxomil are swelling of the legs and feet (peripheral edema), headache, flushing and dizziness. It can also cause an intestinal problem known as sprue-like enteropathy.
Cautions & Contraindications
Warnings & Precautions
Amlodipine and Olmesartan Medoxomil should be used with caution, because there are risks in a few situations. Patients who are low in fluid or salt (volume- or salt-depleted) may develop hypotension. Those with severe aortic stenosis may get vasodilation. And in patients with severe obstructive coronary artery disease, angina or acute MI can become more frequent, last longer or be more severe.
Pregnancy & Breastfeeding
Amlodipine and Olmesartan Medoxomil is Pregnancy Category D. Don't use this combination in the 2nd and 3rd trimester, because it can cause fetal death. If pregnancy is detected, stop the combination as soon as possible.
Nobody knows yet whether olmesartan and amlodipine pass into human milk. Because they could harm a nursing infant, the decision has to be made either to stop nursing or to stop the medicine, and that choice should take into account how important the medicine is to the mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric use: Amlodipine Besilate + Olmesartan Medoxomil has not been shown to be safe or effective in pediatric patients.
Geriatric use: Researchers saw no overall differences in safety or effectiveness between patients aged 65 years or older and younger patients.
Renal impairment: No studies have been done in patients with renal impairment.
Hepatic impairment: Starting treatment with this medicine is not recommended in patients with impaired liver function.
Storage
Store below 30°C, away from light, and out of children's reach.
Drug Interactions
Common questions about Calnor 10 mg+20 mg
What is Calnor 10 mg+20 mg Tablet?
Calnor 10 mg+20 mg Tablet is a medicine that contains Amlodipine Besilate + Olmesartan Medoxomil. It is made by Opsonin Pharma Limited. It belongs to the Combined antihypertensive preparations group of medicines.
What is Calnor used for?
Calnor is used for: Hypertension.
What are the side effects of Calnor?
The most common side effects of Amlodipine Besilate + Olmesartan Medoxomil are swelling of the legs and feet (peripheral edema), headache, flushing and dizziness. It can also cause an intestinal problem known as sprue-like enteropathy.
Can I take Calnor during pregnancy or while breastfeeding?
Amlodipine and Olmesartan Medoxomil is Pregnancy Category D. Don't use this combination in the 2nd and 3rd trimester, because it can cause fetal death. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Calnor?
Store below 30°C, away from light, and out of children's reach.
Can I take other medicines with Calnor?
Some medicines can interact with Amlodipine Besilate + Olmesartan Medoxomil, for example: Olmesartan Medoxomil. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Calnor is already among the lowest-priced brands of Amlodipine Besilate + Olmesartan Medoxomil at this strength.
Do I need a prescription for Calnor?
Calnor is a prescription (Rx) medicine. Take it as your doctor advises.