Amlodipine Besilate + Atenolol
Indications
Amlodipine Besilate + Atenolol is used for patients with essential hypertension. It is also used for patients who have angina pectoris and hypertension together, and for patients after a myocardial infarction (post MI). Doctors also prescribe it for patients with refractory angina pectoris where nitrate therapy has failed.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
This is a fixed-dose combination of Amlodipine and Atenolol. Amlodipine is a dihydropyridine calcium antagonist. It blocks calcium ions from moving into vascular smooth muscle and cardiac muscle across the cell membrane, and its effect is greater on vascular smooth muscle than on cardiac muscle. It is a peripheral vasodilator and acts directly on vascular smooth muscle, so peripheral vascular resistance falls and blood pressure comes down. Amlodipine also reduces tone, decreases coronary vasoreactivity and lowers cardiac demand by reducing afterload.
Atenolol is a cardioselective beta-blocker, and this cardioselectivity is dose-related. It lowers blood pressure by reducing cardiac output, decreasing plasma renin activity and cutting sympathetic outflow from the CNS. Atenolol also reduces myocardial oxygen demand because of its negative inotropic and negative chronotropic effects.
Pregnancy & Breastfeeding
Amlodipine Besilate + Atenolol should be used in pregnancy only when the expected benefit is greater than the possible risk to the baby. Nursing mothers should not take this combination. If the doctor thinks it is necessary, breast-feeding should be stopped.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.