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Same active ingredient — pay up to 50% less
These brands contain the same active ingredient (Amlodipine Besilate + Atenolol). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Calpin Plus
Other strengths and forms by Globe Pharmaceuticals Ltd.
Indications & Uses
Calpin Plus is indicated for:
Pharmacology
This is a fixed-dose combination of Amlodipine and Atenolol. Amlodipine is a dihydropyridine calcium antagonist. It blocks calcium ions from moving into vascular smooth muscle and cardiac muscle across the cell membrane, and its effect is greater on vascular smooth muscle than on cardiac muscle. It is a peripheral vasodilator and acts directly on vascular smooth muscle, so peripheral vascular resistance falls and blood pressure comes down. Amlodipine also reduces tone, decreases coronary vasoreactivity and lowers cardiac demand by reducing afterload.
Atenolol is a cardioselective beta-blocker, and this cardioselectivity is dose-related. It lowers blood pressure by reducing cardiac output, decreasing plasma renin activity and cutting sympathetic outflow from the CNS. Atenolol also reduces myocardial oxygen demand because of its negative inotropic and negative chronotropic effects.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual dose of Amlodipine and Atenolol is one 5/25 mg tablet once daily. If needed, this can be raised to two 5/25 mg tablets daily, or to whatever the physician advises. The dose should still be set for each patient individually.
Side Effects
Amlodipine and Atenolol taken together is well tolerated. The side effects people report include fatigue, headache, edema, nausea, drowsiness, anxiety and depression.
Cautions & Contraindications
Warnings & Precautions
Bronchospasm Amlodipine Besilate + Atenolol should be used with caution in patients with airway obstruction. Renal impairment The combination can be used in patients with renal impairment. Caution may still be necessary if the creatinine clearance is less than 30 ml/min, because the excretion of unchanged Atenolol may be reduced. Hepatic impairment Caution may be necessary when the combination is used in patients with severe liver damage, because the elimination half-life of Amlodipine is prolonged. Drug withdrawal Coronary heart disease can exist without being recognised, so patients should be warned against stopping the medicine suddenly. Any discontinuation should be gradual and under observation.
Contraindications
Amlodipine Besilate + Atenolol should not be given to people who are hypersensitive to either component. It is also not suitable for people with sinus bradycardia, second or higher degrees of heart block, cardiogenic shock, hypotension, congestive heart failure or poor left ventricular function.
Pregnancy & Breastfeeding
Amlodipine Besilate + Atenolol should be used in pregnancy only when the expected benefit is greater than the possible risk to the baby. Nursing mothers should not take this combination. If the doctor thinks it is necessary, breast-feeding should be stopped.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
There are no documented cases for Amlodipine Besilate + Atenolol, but an overdose could cause low blood pressure (hypotension) and, less often, congestive cardiac failure. Any drug still unabsorbed can be removed by gastric lavage or by giving activated charcoal. Treatment is symptomatic.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Amlodipine Besilate + Atenolol below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Calpin Plus 5 mg+50 mg
What is Calpin Plus 5 mg+50 mg Tablet?
Calpin Plus 5 mg+50 mg Tablet is a medicine that contains Amlodipine Besilate + Atenolol. It is made by Globe Pharmaceuticals Ltd. It belongs to the Combined antihypertensive preparations group of medicines.
What is Calpin Plus used for?
Calpin Plus is used for: Hypertension, Angina Pectoris.
What are the side effects of Calpin Plus?
Amlodipine and Atenolol taken together is well tolerated. The side effects people report include fatigue, headache, edema, nausea, drowsiness, anxiety and depression.
Can I take Calpin Plus during pregnancy or while breastfeeding?
Amlodipine Besilate + Atenolol should be used in pregnancy only when the expected benefit is greater than the possible risk to the baby. Nursing mothers should not take this combination. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Calpin Plus?
There are no documented cases for Amlodipine Besilate + Atenolol, but an overdose could cause low blood pressure (hypotension) and, less often, congestive cardiac failure. Any drug still unabsorbed can be removed by gastric lavage or by giving activated charcoal. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Calpin Plus?
Store Amlodipine Besilate + Atenolol below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Calpin Plus?
Some medicines can interact with Amlodipine Besilate + Atenolol, for example: Atenolol, Disopyramide, Ampicillin, Insulin (Human) 30/70. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Locard Plus by Jayson Pharmaceuticals Ltd. has the same ingredient and strength for ৳3.02 per unit, compared with ৳6.00 for Calpin Plus. Ask your doctor or pharmacist before switching.
Do I need a prescription for Calpin Plus?
Calpin Plus is a prescription (Rx) medicine. Take it as your doctor advises.