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Adapalene + Benzoyl Peroxide

Topical retinoid and related preparations Prescription

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Indications

Acne Vulgaris

Nomark gel is a topical treatment for acne vulgaris, used in patients aged 12 years and above.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Adapalene & Benzoyl peroxide gel is used to treat acne vulgaris (acne) in patients 12 years of age and older, applied to the skin. Adapalene attaches to specific retinoic acid receptors inside skin cells but does not attach to cytosolic receptor protein. Studies of its biochemical and pharmacological profile show that Adapalene helps regulate cell differentiation, keratinization, and inflammatory processes in the skin. By binding to these retinoic acid receptors, Adapalene helps normalize the differentiation of follicular epithelial cells, which reduces the formation of microcomedones (the earliest, tiny plugs that lead to acne lesions). Benzoyl peroxide works as an oxidizing agent with bacteria-killing and keratolytic (skin-peeling) effects.

Pregnancy & Breastfeeding

There are no well-controlled studies in pregnant women who have used adapalene and benzoyl peroxide together. Animal reproduction studies have also not been done with this combination gel or with benzoyl peroxide alone. Animal studies don't always predict what happens in people, so this medicine should be used during pregnancy only when the likely benefit outweighs the possible risk to the baby. It isn't known whether adapalene or benzoyl peroxide passes into breast milk after use, so care is needed when it's used by a woman who is breastfeeding.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Apply a thin layer of Adapalene & Benzoyl Peroxide gel once daily to the affected areas of the face and/or trunk, after washing. A pea-sized amount is usually enough to cover each area of the face (for example, the forehead, chin, or a cheek). Keep the gel away from the eyes, lips, and other mucous membranes, and do not use it orally, in the eyes, or vaginally. Pediatric use: This medicine has not been established as safe or effective for children under 12 years of age.