Pricing
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Zonyra is indicated for:
Pharmacology
Trifarotene works as an agonist at the retinoic acid receptors (RAR), and it is particularly active at the gamma subtype of RAR. When these receptors are stimulated, certain target genes are modulated. These genes are linked with several processes, including cell differentiation and the mediation of inflammation. How Trifarotene improves acne is not known exactly.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Put a thin layer of Trifarotene cream on the affected areas once a day, in the evening, on skin that is clean and dry. A moisturizer is recommended, and you can use it as often as you need from the very start of treatment. Keep the cream away from the eyes, lips, paranasal creases and mucous membranes. Trifarotene cream is for use on the skin only. Don't use it by mouth, in the eyes or in the vagina.
Side Effects
The side effects seen in more than 1% of patients using Trifarotene cream were irritation at the place where the cream was applied, itching at the application site, and sunburn.
Cautions & Contraindications
Warnings & Precautions
Skin irritation Trifarotene cream can cause redness (erythema), scaling, dryness and stinging or burning of the skin. These reactions are usually at their worst within the first 4 weeks of treatment, and they ease as the patient keeps using the cream. Depending on how severe the reaction is, patients should be told to use a moisturizer, apply Trifarotene cream less often, or stop using it for a while. If severe reactions don't settle, the treatment may be stopped altogether. Don't apply the cream to cuts, abrasions, or eczematous or sunburned skin. Waxing as a method of hair removal should also be avoided on skin treated with Trifarotene cream. Ultraviolet light and environmental exposure Unprotected exposure to ultraviolet rays (including sunlight and sunlamps) should be kept to a minimum during treatment with Trifarotene cream. Patients who normally get a lot of sun, and those who are naturally sensitive to sun, should be warned to take care. When sun exposure can't be avoided, sunscreen and protective clothing over the treated areas are recommended.
Pregnancy & Breastfeeding
Trifarotene cream is in Pregnancy Category C. Data from clinical trials in pregnant women who used the cream have not shown a drug-related risk of major birth defects, miscarriage, or harmful outcomes for the mother or the baby.
If you are breastfeeding, think about the benefits of breastfeeding for your baby's development and health, and weigh them against your own clinical need for Trifarotene cream. Also consider any possible harm to the breastfed infant, either from the cream or from the mother's underlying condition.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric use: Trifarotene cream hasn't been shown to be safe or effective in children below 9 years of age.
Geriatric use: The clinical trials of Trifarotene cream did not include anyone aged 65 years and over, so it is not known whether older people respond differently from younger people.
Storage
Store Trifarotene below 25°C and away from light. Keep it out of reach of children.
Common questions about Zonyra 0.005%
What is Zonyra 0.005% Cream?
Zonyra 0.005% Cream is a medicine that contains Trifarotene. It is made by Ziska Pharmaceuticals Ltd. It belongs to the Topical retinoid and related preparations group of medicines.
What is Zonyra used for?
Zonyra is used for: Acne Vulgaris.
What are the side effects of Zonyra?
The side effects seen in more than 1% of patients using Trifarotene cream were irritation at the place where the cream was applied, itching at the application site, and sunburn.
Can I take Zonyra during pregnancy or while breastfeeding?
Trifarotene cream is in Pregnancy Category C. Data from clinical trials in pregnant women who used the cream have not shown a drug-related risk of major birth defects, miscarriage, or harmful outcomes for the mother or the baby. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Zonyra?
Store Trifarotene below 25°C and away from light. Keep it out of reach of children.
Do I need a prescription for Zonyra?
Zonyra is a prescription (Rx) medicine. Take it as your doctor advises.