Zeltas

Azelastine Hydrochloride blocks histamine H1 receptors, as shown in isolated tissues. Its main metabolite, desmethylazelastine, has the same H1-receptor blocking activity.

Fluticasone Propionate is a synthetic trifluorinated corticosteroid that reduces inflammation. Exactly how it affects the symptoms of allergic rhinitis is not known. Corticosteroids have been shown to act on many cell types involved in inflammation (for example mast cells, eosinophils, neutrophils, macrophages and lymphocytes etc.) and on many mediators (for example histamine, eicosanoids, leukotrienes and cytokines).

Azelastine Hydrochloride and Fluticasone Propionate Nasal Spray is pregnancy category C. No adequate and well-controlled clinical trials have been done in pregnant women, either with the combination or with Azelastine Hydrochloride only or Fluticasone Propionate only. So the spray should be used in pregnancy only if the possible benefit to the mother justifies the possible risk to the fetus.

Nursing Mothers

It isn't known whether Azelastine Hydrochloride and Fluticasone Propionate Nasal Spray passes into human breast milk. Many drugs do pass into human milk, so caution should be exercised when the spray is given to a nursing woman.

No overdose has been reported with azelastine hydrochloride. If an adult takes too much azelastine hydrochloride in this form of the medicine, serious side effects are unlikely, though they may become more sleepy than usual. Taking too much fluticasone propionate over a long period may cause symptoms of hypercorticism.

Keep Azelastine Hydrochloride + Fluticasone Propionate below 25°C and away from light. Don't put it in the refrigerator. Keep it out of the reach of children.