More from Xripa
Other strengths and forms by Square Pharmaceuticals PLC, Pabna
Indications & Uses
Pharmacology
Nefopam Hydrochloride is a centrally acting pain reliever that starts working quickly. It seems to act mainly within the central nervous system, affecting both the brain and the spinal cord. Laboratory studies indicate that Nefopam blocks the re-uptake of several catecholamines, including noradrenaline, serotonin, and dopamine. This suggests that its pain-relieving effect may come, at least in part, from changing the levels of these neuromodulators in the brain and spinal cord.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Tablet
Adults: the dose can range from 30 to 90 mg three times daily, depending on how the patient responds. The recommended starting dose of Nefopam Hydrochloride is 2 tablets three times daily.
Elderly: older patients may need a lower dose because their metabolism is slower. It is strongly recommended that the starting dose does not go above 1 tablet 3 times daily.
Injection
Adults: 20 mg by IM injection, repeated every 6 hours if necessary. It can also be given by slow IV injection in a similar dose.
Children: Nefopam Hydrochloride is not recommended for children under 12 years of age.
Side Effects
Neforex is generally well tolerated. That said, some effects are seen more often than others. Nausea, nervousness, dry mouth, lightheadedness and difficulty passing urine are the ones reported most frequently. Less commonly, people may notice vomiting, blurred vision, drowsiness, sweating, trouble sleeping, headache, confusion or hallucinations. A fast heartbeat and worsening of angina have also been reported on occasion.
Cautions & Contraindications
Warnings & Precautions
Neforex should be used with caution in patients who have glaucoma or who have or are at risk of urinary retention. Caution should also be exercised when Neforex is given together with tricyclic antidepressants, and in patients with a history of ischaemic heart disease.
Contraindications
Nefopam Hydrochloride should not be used in patients with a history of convulsive disorders, in those taking monoamine oxidase (MAO) inhibitors, or in the treatment of myocardial infarction.
Pregnancy & Breastfeeding
Nefopam Hydrochloride is not recommended for pregnant women. Evidence suggests that nefopam passes into human milk. A decision needs to be made about whether to stop breastfeeding or to stop the medicine. This should weigh the possible harm to the baby against how important the treatment is for the mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Nefopam toxicity shows up as neurological symptoms, which are convulsions, hallucinations and agitation, along with a cardiovascular response of tachycardia with hyperdynamic circulation. Supportive treatment is suggested, and this includes gastric lavage, forced emesis and diuresis. Activated charcoal given by mouth may help prevent absorption. Diazepam may control the convulsions and hallucinations, and beta-adrenergic blockers may be of use for the cardiovascular complications.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Nefopam Hydrochloride below 30°C, away from light and moisture. Keep it out of the reach of children.
Common questions about Xripa 20 mg/ml
What is Xripa 20 mg/ml Injection?
Xripa 20 mg/ml Injection is a medicine that contains Nefopam Hydrochloride. It is made by Square Pharmaceuticals PLC, Pabna. It belongs to the Non-Opioid Analgesics group of medicines.
What is Xripa used for?
Xripa is used for: Pain, Cancer.
What are the side effects of Xripa?
Neforex is generally well tolerated. That said, some effects are seen more often than others.
Can I take Xripa during pregnancy or while breastfeeding?
Nefopam Hydrochloride is not recommended for pregnant women. Evidence suggests that nefopam passes into human milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Xripa?
Nefopam toxicity shows up as neurological symptoms, which are convulsions, hallucinations and agitation, along with a cardiovascular response of tachycardia with hyperdynamic circulation. Supportive treatment is suggested, and this includes gastric lavage, forced emesis and diuresis. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Xripa?
Store Nefopam Hydrochloride below 30°C, away from light and moisture. Keep it out of the reach of children.
Do I need a prescription for Xripa?
Xripa is a prescription (Rx) medicine. Take it as your doctor advises.