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Vaxitet-IG is used to provide short-term (passive) immunity for both preventing and treating tetanus.
Pharmacology
Sterile, clear and faintly yellow to brown, this liquid is tetanus antitoxin (equine) for human use. It contains antitoxic globulins that specifically neutralize the toxin produced by Clostridium tetani, obtained by fractionating the serum of horses hyperimmunized against tetanus toxin.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosage
Prophylaxis of tetanus
Tetanus Antitoxin (equine) should not be used in the routine treatment of traumatic wounds. It is given as prophylaxis to people at risk of tetanus infection from infected or severe wounds. For prophylaxis after injury, people who are non-immune or only partially immune may be given 3,000 to 5,000 units of tetanus antitoxin under the skin (subcutaneously) or into the muscle (intramuscularly). If 24 hours have passed since the wound occurred, the dose is 3,000 III. In crush wounds, or wounds contaminated with soil or other foreign bodies, the dose is 10,000 to 20,000 III. For people below 30 kg, the dose is 1,500 IU. Active immunization with Adsorbed Tetanus vaccine should be given at the same time as this preparation. If the patient has been immunized before, a booster injection of Adsorbed Tetanus vaccine should be given instead.
Treatment
Therapy should be started as soon as possible after the symptoms of the disease appear. The therapeutic dose is not less than 3000 IU. Depending on the severity, the dose may range from 50,000 to 100,000 IU of tetanus antitoxin for hospitalized patients. Part of the dose is given intravenously, and the rest is given intramuscularly.
Side Effects
Hypersensitivity reactions can occur after an injection of any serum derived from animals. In rare cases, this may show up as low blood pressure, breathing difficulty, or hives, and should be managed with adrenaline, sometimes alongside antihistamine and corticosteroid treatment. Serum sickness can also develop 7 to 10 days after receiving an animal-derived serum, presenting with fever, vomiting, diarrhoea, bronchospasm, and hives.
Cautions & Contraindications
Warnings & Precautions
If there is no history of previous serum injection or allergic reaction, the dose of serum may be given intramuscularly. If the patient is subject to allergic diseases, a trial dose of 0.2 ml (diluted 1:10 if preferred) of the serum should be given subcutaneously; if no general reaction develops during an interval of 30 minutes, the main dose may be given intramuscularly. The patient must be kept under observation for at least 30 minutes after the injection, and adrenaline should be kept in readiness for emergency use. In all urgent cases, the intravenous route is indicated, but it should never be used unless a preliminary intramuscular injection, given at least 30 minutes beforehand, has been tolerated. For intravenous use, the serum should be at room temperature, the injection should be given very slowly, and the patient should be lying down during the injection and for at least an hour afterwards.
Contraindications
Tetanus Antitoxin (Equine) should not be given to anyone who has had an allergic reaction to equine protein in the past. People who are known to be allergic in general should not receive it either.
Pregnancy & Breastfeeding
Tetanus Antitoxin (Equine) must not be given during pregnancy.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Tetanus Antitoxin (Equine) out of the reach and sight of children. Store it at +2°C to +8°C, and keep it at the same +2°C to +8 °C during transportation. Don't freeze it, and discard the solution if it has been frozen. Protect it from light.
Common questions about Vaxitet-IG 3000 IU/ml
What is Vaxitet-IG 3000 IU/ml IM Injection?
Vaxitet-IG 3000 IU/ml IM Injection is a medicine that contains Tetanus Antitoxin (Equine). It is made by Incepta Pharmaceuticals Ltd. It belongs to the Vaccines group of medicines.
What is Vaxitet-IG used for?
Vaxitet-IG is used to provide short-term (passive) immunity for both preventing and treating tetanus.
What are the side effects of Vaxitet-IG?
Hypersensitivity reactions can occur after an injection of any serum derived from animals. In rare cases, this may show up as low blood pressure, breathing difficulty, or hives, and should be managed with adrenaline, sometimes alongside antihistamine and corticosteroid treatment.
Can I take Vaxitet-IG during pregnancy or while breastfeeding?
Tetanus Antitoxin (Equine) must not be given during pregnancy. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Vaxitet-IG?
Keep Tetanus Antitoxin (Equine) out of the reach and sight of children. Store it at +2°C to +8°C, and keep it at the same +2°C to +8 °C during transportation.
Do I need a prescription for Vaxitet-IG?
Vaxitet-IG is a prescription (Rx) medicine. Take it as your doctor advises.