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Typhoid conjugate vaccine is used for active immunization against infection caused by Salmonella typhi. It can be given to infants, children, adolescents and adults who are older than 6 months and younger than 45 years.
Pharmacology
Typhoid Vi Conjugate Vaccine is a clear, colourless solution with no visible particles in it. Each dose contains 25 mcg of Typhoid Vi polysaccharide conjugated to CRMt97. The polysaccharide is made using Citrobacter freundii sensu lato 3056 (Vi) and is conjugated to CRM197, which acts as the carrier protein. Sodium Chloride and Phosphate Buffer are used as the diluent (buffering agent) in the formulation, and 2-Phenoxyethanol is added as a preservative.
BE's Typhoid Vi Conjugate Vaccine can be given as a single 0.5 mL intramuscular dose to infants, children, adolescents and adults aged >6 months to <45 years. The vaccine meets the requirements of I.P. and WHO.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Give the typhoid conjugate vaccine as a single 0.5 mL dose, injected into the muscle (intramuscularly). For children aged 2 years and above, adolescents and adults, the usual site is the deltoid muscle of the upper arm, provided the muscle mass is adequate.
For infants and toddlers aged more than 6 months and under 2 years, inject it into the vastus lateralis muscle, on the front and outer side of the thigh.
Don't inject the vaccine into the gluteal area, or into any area where there may be a nerve trunk.
Side Effects
In the clinical trial of Biological E's Typhoid conjugate vaccine (Vi Conjugate vaccine), the local reactions reported most often were injection site pain (4.50%), injection site erythema (0.64%) and injection site swelling (0.32%). These usually began within the first 48 hours and cleared up within 2 to 3 days. The systemic side effects reported most often were pyrexia (2.25%), vomiting (0.96%), headache (0.64%), fatigue (0.64%), arthralgia (0.32%) and rash (0.32%). No serious adverse events (SAEs) linked to the vaccine were reported in the trial.
Cautions & Contraindications
Warnings & Precautions
Don't give typhoid conjugate vaccine into a vein, into the skin (intradermally) or under the skin (subcutaneously). Typhoid conjugate vaccine protects against typhoid fever caused by Salmonella typhi. It does not protect against Salmonella paratyphi or other non typhoidal Salmonellae. Keep adrenaline (epinephrine) injection, 1:1000 (1 mg/mL), ready for immediate use in case of an acute anaphylactic reaction, or any allergic reaction to a component of the vaccine. The person vaccinated should stay under medical supervision for not less than 30 minutes after the injection. As with all other vaccines, supervision and proper medical treatment must always be available to treat any anaphylactic reaction after immunization.
Pregnancy & Breastfeeding
Nobody has established whether typhoid conjugate vaccine is safe or effective in pregnant women or in nursing mothers. It is also not known whether the vaccine passes into human milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store typhoid conjugate vaccine at +2°C to +8°C. Do not freeze it, and throw it away if it has been frozen. Shake well before use. Keep it out of reach of children.
Common questions about Typhibev 0.5 ml
What is Typhibev 0.5 ml IM Injection?
Typhibev 0.5 ml IM Injection is a medicine that contains Typhoid conjugate vaccine. It is made by Janata Traders. It belongs to the Vaccines group of medicines.
What is Typhibev used for?
Typhoid conjugate vaccine is used for active immunization against infection caused by Salmonella typhi. It can be given to infants, children, adolescents and adults who are older than 6 months and younger than 45 years.
What are the side effects of Typhibev?
In the clinical trial of Biological E's Typhoid conjugate vaccine (Vi Conjugate vaccine), the local reactions reported most often were injection site pain (4.50%), injection site erythema (0.64%) and injection site swelling (0.32%). These usually began within the first 48 hours and cleared up within 2 to 3 days.
Can I take Typhibev during pregnancy or while breastfeeding?
Nobody has established whether typhoid conjugate vaccine is safe or effective in pregnant women or in nursing mothers. It is also not known whether the vaccine passes into human milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Typhibev?
Store typhoid conjugate vaccine at +2°C to +8°C. Do not freeze it, and throw it away if it has been frozen.
Do I need a prescription for Typhibev?
Typhibev is a prescription (Rx) medicine. Take it as your doctor advises.