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Indications & Uses
Trospi is used for the symptomatic treatment of urge incontinence, and for increased urinary frequency and urgency, which can occur in people with overactive bladder (for example idiopathic or neurologic detrusor overactivity).
Pharmacology
Trospium chloride is a muscarinic antagonist. It blocks the effect of acetylcholine on muscarinic receptors in organs supplied by cholinergic nerves, and the bladder is one of these. This parasympatholytic action lowers the tonus of the smooth muscle in the bladder. Receptor assays showed that at the concentrations reached with therapeutic doses, trospium chloride has negligible affinity for nicotinic receptors compared with muscarinic receptors.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual dose of Trospium Chloride is one 20 mg tablet twice daily. The doctor should look again at whether you still need the treatment at regular intervals of 3 to 6 months. Swallow the film-coated tablet whole with a glass of water, before meals, on an empty stomach.
Renal impairment: for patients with severe renal impairment (CrCl<30 mL/min), the recommended dose is 20 mg once daily at bedtime.
In geriatric patients aged 75 years or more, the dose may be reduced to 20 mg once daily, depending on how well the patient tolerates it.
Pediatric use: the safety and efficacy of Trospium Chloride 20 mg film-coated tablets in children under 12 years of age have not been established. No data are available.
Side Effects
Trospi has been linked with the following side effects since it came into use after approval. These reactions were reported voluntarily by a population of uncertain size, so it isn't always possible to estimate how often they happen or to prove that the medicine caused them. Gastrointestinal: gastritis Cardiovascular: palpitations, supraventricular tachycardia, chest pain, syncope, hypertensive crisis Immunological: Stevens-Johnson syndrome, anaphylactic reaction, angioedema Nervous System: dizziness, confusion, vision abnormal, hallucinations, somnolence and delirium Musculoskeletal: rhabdomyolysis General: rash
Cautions & Contraindications
Warnings & Precautions
Trospi (trospium chloride) should be used with caution in patients who have obstructive conditions of the gastrointestinal tract, such as pyloric stenosis. The same care applies to patients with obstruction of urinary flow, where urinary retention may develop, and to those with autonomic neuropathy or a hiatus hernia associated with reflux oesophagitis. It also applies where a fast heart rate is undesirable, for example in hyperthyroidism, coronary artery disease and congestive heart failure. Precautions: Hepatic impairment. There are no data in patients with severe hepatic impairment, so treating these patients with Trospi is not recommended. In patients with mild to moderate liver impairment, caution should be exercised. Precautions: Renal impairment. Trospi is mainly eliminated by renal excretion, and marked rises in plasma levels have been seen in patients with severe renal impairment. So caution should be exercised in these patients, and also in those with mild to moderate renal impairment. Before starting treatment, organic causes of urinary frequency, urgency and urge incontinence should be excluded. These include heart diseases, diseases of the kidneys, polydipsia, infections, and tumours of the urinary organs.
Contraindications
Trospium Chloride must not be given to patients with urinary retention, a severe gastro-intestinal condition (including toxic megacolon), myasthenia gravis, narrow-angle glaucoma or tachyarrhythmia. It is also contra-indicated in anyone who has shown hypersensitivity to the active substance or to any of the excipients.
Pregnancy & Breastfeeding
Studies in animals show no direct or indirect harmful effects on pregnancy, on the development of the embryo or foetus, on childbirth, or on development after birth. In rats, Trospium Chloride does cross the placenta and pass into the mother's milk. For Trospium Chloride 20mg film-coated tablets, there are no clinical data on pregnancies where the medicine was taken. Caution should be taken when prescribing it to pregnant or breastfeeding women.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Healthy volunteers who took a single dose of 360 mg Trospi (Trospium Chloride), the highest dose given, had more dry mouth, fast heartbeat (tachycardia) and trouble passing urine than usual. No severe overdose or poisoning has been reported in humans so far. If poisoning does happen, stronger anticholinergic symptoms are what you would expect to see.
The following steps should be taken in case of poisoning: gastric lavage and reducing absorption (for example with activated charcoal), pilocarpine given locally to patients with glaucoma, catheterisation for patients with urinary retention, and a parasympathomimetic agent (for example neostigmine) if the symptoms are severe. If the response is not enough, or there is pronounced tachycardia and/or unstable circulation, give beta blockers (for example 1 mg propranolol intravenously to start with, while monitoring the ECG and blood pressure).
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Trospium Chloride in a dry place, below 30ºC, and protect it from light.
Drug Interactions
Common questions about Trospi 20 mg
What is Trospi 20 mg Tablet?
Trospi 20 mg Tablet is a medicine that contains Trospium Chloride. It is made by Unimed Unihealth Pharmaceuticals Ltd. It belongs to the Other genito-urinary preparations group of medicines.
What is Trospi used for?
Trospi is used for the symptomatic treatment of urge incontinence, and for increased urinary frequency and urgency, which can occur in people with overactive bladder (for example idiopathic or neurologic detrusor overactivity).
What are the side effects of Trospi?
Trospi has been linked with the following side effects since it came into use after approval. These reactions were reported voluntarily by a population of uncertain size, so it isn't always possible to estimate how often they happen or to prove that the medicine caused them.
Can I take Trospi during pregnancy or while breastfeeding?
Studies in animals show no direct or indirect harmful effects on pregnancy, on the development of the embryo or foetus, on childbirth, or on development after birth. In rats, Trospium Chloride does cross the placenta and pass into the mother's milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Trospi?
Healthy volunteers who took a single dose of 360 mg Trospi (Trospium Chloride), the highest dose given, had more dry mouth, fast heartbeat (tachycardia) and trouble passing urine than usual. No severe overdose or poisoning has been reported in humans so far. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Trospi?
Keep Trospium Chloride in a dry place, below 30ºC, and protect it from light.
Can I take other medicines with Trospi?
Some medicines can interact with Trospium Chloride, for example: Digoxin, Cholestyramine, Amantadine Hydrochloride. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Trospi is already among the lowest-priced brands of Trospium Chloride at this strength.
Do I need a prescription for Trospi?
Trospi is a prescription (Rx) medicine. Take it as your doctor advises.