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These brands contain the same active ingredient (Levofloxacin Hemihydrate). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Toplevo
Other strengths and forms by NIPRO JMI Pharma Limited
Indications & Uses
Toplevo is indicated for:
Pharmacology
Levofloxacin is a synthetic, broad-spectrum antibiotic from the third generation of fluoroquinolones. Chemically, it is a chiral fluorinated carboxyquinolone. It works against bacteria by blocking two enzymes, bacterial topoisomerase IV and DNA gyrase, which the bacteria need for DNA replication, transcription repair and recombination. In laboratory (in vitro) tests, levofloxacin has shown activity against a wide range of gram-negative and gram-positive microorganisms.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Levofloxacin tablets are usually taken as 250 mg, 500 mg or 750 mg by mouth every 24 hours. The tablets can be taken with or without food. The oral solution should be taken 1 hour before, or 2 hours after eating.
Levofloxacin injection is given only by intravenous infusion. It is not for intramuscular, intrathecal, intraperitoneal or subcutaneous use. The usual dose is 250 mg or 500 mg by slow infusion over 60 minutes every 24 hours, or 750 mg by slow infusion over 90 minutes every 24 hours. The injection is for single use only, so any unused portion should be thrown away. Don't add other additives or medicines to it, and don't infuse anything else at the same time through the same intravenous line.
Adults:
For acute sinusitis, the dose is 500 mg once daily for 10 to 14 days, or 750 mg once daily for 5 days. For an exacerbation of chronic bronchitis, it is 500 mg once daily for 7 days, or 750 mg once daily for 3 days (uncomplicated) or for 5 days (complicated). Community-acquired pneumonia is treated with 500 mg once daily for 7 to 14 days, or 750 mg once daily for 5 days.
Uncomplicated urinary-tract infections need 250 mg once daily for 3 days. Complicated urinary-tract infections and acute pyelonephritis need 250 mg once daily for 7 to 10 days. For uncomplicated skin and soft-tissue infections the dose is 500 mg once daily for 7 to 10 days, and for complicated ones it is 750 mg once daily for 7 to 14 days. Enteric fever is treated with 500 mg once daily for 7 to 14 days.
For diarrhea, cholera, shigellosis and enteritis, a mild to moderate case needs 500 mg as a single dose. A moderate to severe case needs 500 mg once daily for 3 days.
Children:
Children from 6 months to under 5 years get 10 mg/kg every 12 hours. Children over 5 years get 10 mg/kg every 24 hours.
In each case, the physician may decide to move the patient from intravenous to oral treatment (sequential therapy).
Side Effects
Levofloxacin Hemihydrate is generally well tolerated, though a few side-effects can usually be seen. There is a risk of retinal detachment. Other side-effects include nausea, vomiting, diarrhea, abdominal pain and flatulence. Phototoxicity can also occur, but it is rare (0.1%). Very rarely, people may have tremors, depression, anxiety, confusion and similar effects.
Cautions & Contraindications
Warnings & Precautions
Levofloxacin Hemihydrate Injection must be given only as a slow intravenous infusion, over 60 or 90 minutes depending on the dose. While a patient is on Levofloxacin Hemihydrate, they should drink enough water so the urine does not become concentrated. If the patient has renal insufficiency, the dose needs to be adjusted.
Contraindications
Don't give Levofloxacin to anyone who has had a hypersensitivity reaction to levofloxacin, to any other quinolone antimicrobial agent, or to any of the other components in the product.
Pregnancy & Breastfeeding
Doctors don't recommend levofloxacin during pregnancy or while breastfeeding, because its effects on an unborn child or a nursing infant are not known.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Levofloxacin Hemihydrate has a low potential for acute toxicity. Even so, if someone takes an acute overdose, the stomach should be emptied. The patient should be kept under observation, and proper hydration should be maintained.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Levofloxacin Hemihydrate below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Toplevo 500 mg
What is Toplevo 500 mg Tablet?
Toplevo 500 mg Tablet is a medicine that contains Levofloxacin Hemihydrate. It is made by NIPRO JMI Pharma Limited. It belongs to the 4-Quinolone preparations group of medicines.
What is Toplevo used for?
Toplevo is used for: Chronic Obstructive Pulmonary Disease, Pneumonia, Bronchitis, Sinusitis, Skin and Soft Tissue Infection.
What are the side effects of Toplevo?
Levofloxacin Hemihydrate is generally well tolerated, though a few side-effects can usually be seen. There is a risk of retinal detachment.
Can I take Toplevo during pregnancy or while breastfeeding?
Doctors don't recommend levofloxacin during pregnancy or while breastfeeding, because its effects on an unborn child or a nursing infant are not known. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Toplevo?
Levofloxacin Hemihydrate has a low potential for acute toxicity. Even so, if someone takes an acute overdose, the stomach should be emptied. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Toplevo?
Store Levofloxacin Hemihydrate below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Toplevo?
Some medicines can interact with Levofloxacin Hemihydrate, for example: Warfarin Sodium, Iron, Magnesium. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Teriflox by Union Pharmaceuticals Ltd. has the same ingredient and strength for ৳8.00 per unit, compared with ৳16.00 for Toplevo. Ask your doctor or pharmacist before switching.
Do I need a prescription for Toplevo?
Toplevo is a prescription (Rx) medicine. Take it as your doctor advises.