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Other brands with the same active ingredient
These brands contain the same active ingredient (Propafenone Hydrochloride). Same strength and form. Confirm the switch with your doctor or pharmacist.
Rythmosin 150
Rx150 mg • Tablet
Indications & Uses
Rythmosin 150 is indicated for:
Pharmacology
Propafenone works by slowing the entry of sodium ions into heart muscle cells, which makes those cells less excitable. It acts more selectively on cells that are firing at a high rate, though it also affects normal heart cells more than class Ia or Ib agents do. Unlike a typical class Ic antiarrhythmic, propafenone also has beta-blocking activity, which can lead to a slowed heart rate (bradycardia) and airway narrowing (bronchospasm).
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The dose of Propafenone has to be worked out for each patient, based on how well it works and how well the patient tolerates it. Treatment usually starts at 150 mg every eight hours, which comes to 450 mg a day.
If needed, the dose can be raised to 225 mg every 8 hours (675 mg/day), with at least 3 to 4 days between increases. A further rise to 300 mg every 8 hours (900 mg/day) is possible if necessary. Doses above 900 mg a day have not been shown to be useful or safe.
Side Effects
Adverse effects most often involve the digestive system, heart and blood vessels, and nervous system. Some people notice a change in taste, constipation, diarrhea, dizziness, drowsiness, a dry mouth, gas, headache, light-headedness, nausea, or tiredness, among other effects. Severe allergic reactions have also been reported with this medicine.
Cautions & Contraindications
Warnings & Precautions
Hepatic Dysfunction Rythmosin is broken down heavily by the liver, so it should be given with care to patients whose liver function is impaired. For these patients, the dose of propafenone should be about 20 to 30% of the dose given to patients with normal liver function. Renal Dysfunction A fair share of the propafenone metabolites leaves the body in the urine (18.5% to 38% of the dose over 48 hours). Until more data are available, propafenone should be given cautiously to patients with impaired kidney function. Neuromuscular Dysfunction Worsening of myasthenia gravis has been reported in patients taking propafenone.
Contraindications
Propafenone should not be used in people with uncontrolled congestive heart failure, cardiogenic shock, or disorders of impulse generation and/or conduction in the sinoatrial, atrioventricular, or intraventricular pathways (such as sick sinus node syndrome or atrioventricular block) unless an artificial pacemaker is in place. It is also contraindicated in bradycardia, marked hypotension, bronchospastic disorders, significant electrolyte imbalance, and known hypersensitivity to the drug.
Pregnancy & Breastfeeding
Pregnancy: The FDA has placed propafenone in pregnancy category C. There are no well-controlled studies in pregnant women. A small amount of limited data shows that propafenone has been given during the third trimester without any harmful effects on the mother or the baby. So it should be used during pregnancy only when the benefit to the mother is greater than the risk.
Breastfeeding: It isn't known whether this medicine passes into human milk. Many medicines do, and propafenone could cause serious side effects in a nursing baby. So the doctor needs to decide whether to stop breastfeeding or stop the medicine, taking into account how important the medicine is for the mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric Use: The safety and effectiveness of propafenone in children have not been established.
Geriatric Use: Clinical studies of propafenone did not include enough people aged 65 and over to show whether they respond differently from younger patients. In general, the dose for an elderly patient should be chosen with care.
Storage
Keep Propafenone Hydrochloride at 25° C, in a cool and dry place, away from light. Keep it out of children's reach.
Drug Interactions
Common questions about Rythmosin 150 150 mg
What is Rythmosin 150 150 mg Tablet?
Rythmosin 150 150 mg Tablet is a medicine that contains Propafenone Hydrochloride. It is made by Unimed Unihealth Pharmaceuticals Ltd. It belongs to the Membrane stabilizing agent (Sodium channel blockers) group of medicines.
What is Rythmosin 150 used for?
Rythmosin 150 is used for: Cardiac Arrhythmia.
What are the side effects of Rythmosin 150?
Adverse effects most often involve the digestive system, heart and blood vessels, and nervous system. Some people notice a change in taste, constipation, diarrhea, dizziness, drowsiness, a dry mouth, gas, headache, light-headedness, nausea, or tiredness, among other effects.
Can I take Rythmosin 150 during pregnancy or while breastfeeding?
Pregnancy: The FDA has placed propafenone in pregnancy category C. There are no well-controlled studies in pregnant women. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Rythmosin 150?
Keep Propafenone Hydrochloride at 25° C, in a cool and dry place, away from light. Keep it out of children's reach.
Can I take other medicines with Rythmosin 150?
Some medicines can interact with Propafenone Hydrochloride, for example: Tizanidine Hydrochloride, Erythromycin, Haloperidol, Sertraline, Venlafaxine, Paroxetine. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Rythmosin 150?
Rythmosin 150 is a prescription (Rx) medicine. Take it as your doctor advises.